Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts (N7-methylguanine and N3-methyladenine) and some O6-methylguanine (O6mG) adducts. Current models propose that during DNA replication, thymine is i...

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Bibliographic Details
Main Authors: Robert P Fuchs, Asako Isogawa, Joao A Paulo, Kazumitsu Onizuka, Tatsuro Takahashi, Ravindra Amunugama, Julien P Duxin, Shingo Fujii
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
mismatch repair
base excision repair crosstalk
sn1 versus sn2
alkylating agents
unbiased dna
binding proteins discovery
Online Access:https://elifesciences.org/articles/69544

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