Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease
Ocular toxoplasmosis can result in recurrent uveitis. Studies have shown that a correlation between active ocular toxoplasmosis and the presence of anti-Toxoplasma gondii secretory IgA (SIgA) in tears. This study compares anti-T. gondii SIgA levels in patients' tears during the acute and inacti...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500017&lng=en&tlng=en |
| _version_ | 1797717994178084864 |
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| author | Luiz Felipe Lynch Maria Isabel Lynch Rodrigo Santana do Nascimento Ferreira Mirelle Souza Leão Vasconcelos Narjara Melo Silvana Ferreira Elizabeth Malagueño |
| author_facet | Luiz Felipe Lynch Maria Isabel Lynch Rodrigo Santana do Nascimento Ferreira Mirelle Souza Leão Vasconcelos Narjara Melo Silvana Ferreira Elizabeth Malagueño |
| author_sort | Luiz Felipe Lynch |
| collection | DOAJ |
| description | Ocular toxoplasmosis can result in recurrent uveitis. Studies have shown that a correlation between active ocular toxoplasmosis and the presence of anti-Toxoplasma gondii secretory IgA (SIgA) in tears. This study compares anti-T. gondii SIgA levels in patients' tears during the acute and inactive phases of toxoplasmic uveitis. Twenty-nine positive tear specific SIgA for T. gondii patients with acute toxoplasmic uveitis were selected and were followed-up for at least two years, when the anti-T. gondii SIgA tears levels were determined. Specific SIgA for T. gondii was negative in 22 patients (75.86%) and positive in seven patients (24.13%) of whom six (85.7%) were followed over three years. Average SIgA levels during the acute phase are 1.54 and decrease significantly to 0.72 (p = 0.0001) during the inactive phase of disease. Because anti-T. gondii SIgA in the tear is negative in 75.86% of patients after the acute phase of infection, T. gondii SIgA levels may be used as a complementary diagnostic marker for active ocular toxoplasmosis. |
| first_indexed | 2024-03-12T08:45:28Z |
| format | Article |
| id | doaj.art-0d6850f213b4437c845006ec4a133049 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:45:28Z |
| publishDate | 2011-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0d6850f213b4437c845006ec4a1330492023-09-02T16:28:31ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-08-01106562562810.1590/S0074-02762011000500017S0074-02762011000500017Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the diseaseLuiz Felipe Lynch0Maria Isabel Lynch1Rodrigo Santana do Nascimento Ferreira2Mirelle Souza Leão Vasconcelos3Narjara Melo4Silvana Ferreira5Elizabeth Malagueño6Universidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoOcular toxoplasmosis can result in recurrent uveitis. Studies have shown that a correlation between active ocular toxoplasmosis and the presence of anti-Toxoplasma gondii secretory IgA (SIgA) in tears. This study compares anti-T. gondii SIgA levels in patients' tears during the acute and inactive phases of toxoplasmic uveitis. Twenty-nine positive tear specific SIgA for T. gondii patients with acute toxoplasmic uveitis were selected and were followed-up for at least two years, when the anti-T. gondii SIgA tears levels were determined. Specific SIgA for T. gondii was negative in 22 patients (75.86%) and positive in seven patients (24.13%) of whom six (85.7%) were followed over three years. Average SIgA levels during the acute phase are 1.54 and decrease significantly to 0.72 (p = 0.0001) during the inactive phase of disease. Because anti-T. gondii SIgA in the tear is negative in 75.86% of patients after the acute phase of infection, T. gondii SIgA levels may be used as a complementary diagnostic marker for active ocular toxoplasmosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500017&lng=en&tlng=enuveitisocular toxoplasmosissecretory IgAtears |
| spellingShingle | Luiz Felipe Lynch Maria Isabel Lynch Rodrigo Santana do Nascimento Ferreira Mirelle Souza Leão Vasconcelos Narjara Melo Silvana Ferreira Elizabeth Malagueño Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease Memorias do Instituto Oswaldo Cruz uveitis ocular toxoplasmosis secretory IgA tears |
| title | Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease |
| title_full | Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease |
| title_fullStr | Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease |
| title_full_unstemmed | Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease |
| title_short | Ocular toxoplasmosis: evaluation of lacrimal - specific secretory IgA levels in both patients with active and inactive phases of the disease |
| title_sort | ocular toxoplasmosis evaluation of lacrimal specific secretory iga levels in both patients with active and inactive phases of the disease |
| topic | uveitis ocular toxoplasmosis secretory IgA tears |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500017&lng=en&tlng=en |
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