Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry
Any movement performed repeatedly will be executed with inter-trial variability. Oropharyngeal swallowing is a complex sensorimotor action, and swallow-to-swallow variability can have consequences that impact swallowing safety. Our aim was to determine an appropriate method to measure swallowing pre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Applied Mathematics and Statistics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fams.2018.00023/full |
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| author | Corinne A. Jones Corinne A. Jones Corinne A. Jones Ellen L. Meisner Ellen L. Meisner Courtney K. Broadfoot Courtney K. Broadfoot Sarah P. Rosen Christine R. Samuelsen Timothy M. McCulloch Timothy M. McCulloch |
| author_facet | Corinne A. Jones Corinne A. Jones Corinne A. Jones Ellen L. Meisner Ellen L. Meisner Courtney K. Broadfoot Courtney K. Broadfoot Sarah P. Rosen Christine R. Samuelsen Timothy M. McCulloch Timothy M. McCulloch |
| author_sort | Corinne A. Jones |
| collection | DOAJ |
| description | Any movement performed repeatedly will be executed with inter-trial variability. Oropharyngeal swallowing is a complex sensorimotor action, and swallow-to-swallow variability can have consequences that impact swallowing safety. Our aim was to determine an appropriate method to measure swallowing pressure waveform variability. An ideal variability metric must be sensitive to known deviations in waveform amplitude, duration, and overall shape, without being biased by waveforms that have both positive and sub-atmospheric pressure profiles. Through systematic analysis of model waveforms, we found a coefficient of variability (CV) parameter on waveforms adjusted such that the overall mean was 0 to be best suited for swallowing pressure variability analysis. We then investigated pharyngeal swallowing pressure variability using high-resolution manometry data from healthy individuals to assess impacts of waveform alignment, pharyngeal region, and number of swallows investigated. The alignment that resulted in the lowest overall swallowing pressure variability was when the superior-most sensor in the upper esophageal sphincter (UES) reached half its maximum pressure. Pressures in the tongue base region of the pharynx were least variable and pressures in the hypopharynx region were most variable. Sets of 3–10 consecutive swallows had no overall difference in variability, but sets of two swallows resulted in significantly less variability than the other dataset sizes. This study identified variability in swallowing pressure waveform shape throughout the pharynx in healthy adults; we discuss implications for swallowing motor control. |
| first_indexed | 2024-04-13T06:36:14Z |
| format | Article |
| id | doaj.art-0d690a7e96f145468f1d5944f49e2966 |
| institution | Directory Open Access Journal |
| issn | 2297-4687 |
| language | English |
| last_indexed | 2024-04-13T06:36:14Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Applied Mathematics and Statistics |
| spelling | doaj.art-0d690a7e96f145468f1d5944f49e29662022-12-22T02:57:54ZengFrontiers Media S.A.Frontiers in Applied Mathematics and Statistics2297-46872018-07-01410.3389/fams.2018.00023378622Methods for Measuring Swallowing Pressure Variability Using High-Resolution ManometryCorinne A. Jones0Corinne A. Jones1Corinne A. Jones2Ellen L. Meisner3Ellen L. Meisner4Courtney K. Broadfoot5Courtney K. Broadfoot6Sarah P. Rosen7Christine R. Samuelsen8Timothy M. McCulloch9Timothy M. McCulloch10Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDepartment of Communication Sciences & Disorders, University of Wisconsin – Madison, Madison, WI, United StatesNeuroscience Training Program, University of Wisconsin – Madison, Madison, WI, United StatesDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDepartment of Physical Therapy, Mayo Clinic School of Health Sciences, Rochester, MN, United StatesDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDepartment of Communication Sciences & Disorders, University of Wisconsin – Madison, Madison, WI, United StatesDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin – Madison, Madison, WI, United StatesDepartment of Communication Sciences & Disorders, University of Wisconsin – Madison, Madison, WI, United StatesAny movement performed repeatedly will be executed with inter-trial variability. Oropharyngeal swallowing is a complex sensorimotor action, and swallow-to-swallow variability can have consequences that impact swallowing safety. Our aim was to determine an appropriate method to measure swallowing pressure waveform variability. An ideal variability metric must be sensitive to known deviations in waveform amplitude, duration, and overall shape, without being biased by waveforms that have both positive and sub-atmospheric pressure profiles. Through systematic analysis of model waveforms, we found a coefficient of variability (CV) parameter on waveforms adjusted such that the overall mean was 0 to be best suited for swallowing pressure variability analysis. We then investigated pharyngeal swallowing pressure variability using high-resolution manometry data from healthy individuals to assess impacts of waveform alignment, pharyngeal region, and number of swallows investigated. The alignment that resulted in the lowest overall swallowing pressure variability was when the superior-most sensor in the upper esophageal sphincter (UES) reached half its maximum pressure. Pressures in the tongue base region of the pharynx were least variable and pressures in the hypopharynx region were most variable. Sets of 3–10 consecutive swallows had no overall difference in variability, but sets of two swallows resulted in significantly less variability than the other dataset sizes. This study identified variability in swallowing pressure waveform shape throughout the pharynx in healthy adults; we discuss implications for swallowing motor control.https://www.frontiersin.org/article/10.3389/fams.2018.00023/fulldeglutitionpressurevariabilityhigh-resolution manometrypharyngeal pressure |
| spellingShingle | Corinne A. Jones Corinne A. Jones Corinne A. Jones Ellen L. Meisner Ellen L. Meisner Courtney K. Broadfoot Courtney K. Broadfoot Sarah P. Rosen Christine R. Samuelsen Timothy M. McCulloch Timothy M. McCulloch Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry Frontiers in Applied Mathematics and Statistics deglutition pressure variability high-resolution manometry pharyngeal pressure |
| title | Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry |
| title_full | Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry |
| title_fullStr | Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry |
| title_full_unstemmed | Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry |
| title_short | Methods for Measuring Swallowing Pressure Variability Using High-Resolution Manometry |
| title_sort | methods for measuring swallowing pressure variability using high resolution manometry |
| topic | deglutition pressure variability high-resolution manometry pharyngeal pressure |
| url | https://www.frontiersin.org/article/10.3389/fams.2018.00023/full |
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