Study on liver histopathology of chronic HBV infected patients with different normal ALT values
AimsComparison of liver histopathological findings to explore the occurrence of liver inflammation in patients with chronic hepatitis B (CHB) under different alanine aminotransferase (ALT) normal values.MethodsThe patients who were diagnosed as chronic hepatitis B virus (HBV) infection by liver hist...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069752/full |
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| author | Zhan Zeng Zhan Zeng Hongxiao Hao Xiaoyue Bi Yanjie Lin Liu Yang Shiyu Wang Ge Shen Min Chang Tingting Jiang Wen Deng Huihui Lu Fangfang Sun Yao Lu Yuanjiao Gao Ruyu Liu Mengjiao Xu Xiaoxue Chen Leiping Hu Lu Zhang Minghui Li Minghui Li Yao Xie Yao Xie |
| author_facet | Zhan Zeng Zhan Zeng Hongxiao Hao Xiaoyue Bi Yanjie Lin Liu Yang Shiyu Wang Ge Shen Min Chang Tingting Jiang Wen Deng Huihui Lu Fangfang Sun Yao Lu Yuanjiao Gao Ruyu Liu Mengjiao Xu Xiaoxue Chen Leiping Hu Lu Zhang Minghui Li Minghui Li Yao Xie Yao Xie |
| author_sort | Zhan Zeng |
| collection | DOAJ |
| description | AimsComparison of liver histopathological findings to explore the occurrence of liver inflammation in patients with chronic hepatitis B (CHB) under different alanine aminotransferase (ALT) normal values.MethodsThe patients who were diagnosed as chronic hepatitis B virus (HBV) infection by liver histopathology at the Department of Pathology, Beijing Ditan Hospital due to clinical difficulty in defining the degree of liver inflammation or fibrosis were retrospectively enrolled from May 2008 to November 2020. Study of the incidence of significant hepatic histopathology in enrolled patients according to different ALT normal values. Using logistic regression to investigate the relevant factors of significant hepatic histopathology.ResultsA total of 1474 patients were enrolled, 56.20% of the patients were male, and the overall patients’ age was 36.80 ± 10.60 years. 39.00% of patients had liver inflammation grade G > 1, 34.70% liver fibrosis stage S > 1, and 48.17% patients had significant hepatic histopathology (G > 1 and/or S > 1). Among patients with normal ALT values, 36.40% and 40.40% had significant hepatic histopathology by American Association for the Study of Liver Diseases (AASLD) criteria and Chinese guideline criteria, respectively, but the difference was not statistically significant (χ2 =3.38, P =0.066). In contrast, among patients with abnormal ALT values, 58.90% and 62.20% of patients had significant hepatic histopathology by AASLD criteria and Chinese guideline criteria, respectively, with no significant difference (χ2 =2.28, P =0.131). ALT (P <0.001, OR=1.019), hepatitis B surface antigen (HBsAg) (P <0.001, OR=0.665) and hepatitis B e antigen (HBeAg) status (P <0.001, OR=2.238) were relevant factors in the occurrence of significant hepatic histopathology. ALT was positively corelated with grade of inflammation G (r =0.194, P <0.001) and negatively correlated with liver fibrosis stage S (r =-0.066, P =0.021).ConclusionsOur study found no statistically significant differences in the presence of significant hepatic histopathology under the two ALT criteria. ALT, HBsAg and HBeAg status were related to the occurrence of significant hepatic histopathology. |
| first_indexed | 2024-04-13T12:36:01Z |
| format | Article |
| id | doaj.art-0d6aec048dfa4da9b8c16c7f226949f6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T12:36:01Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0d6aec048dfa4da9b8c16c7f226949f62022-12-22T02:46:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10697521069752Study on liver histopathology of chronic HBV infected patients with different normal ALT valuesZhan Zeng0Zhan Zeng1Hongxiao Hao2Xiaoyue Bi3Yanjie Lin4Liu Yang5Shiyu Wang6Ge Shen7Min Chang8Tingting Jiang9Wen Deng10Huihui Lu11Fangfang Sun12Yao Lu13Yuanjiao Gao14Ruyu Liu15Mengjiao Xu16Xiaoxue Chen17Leiping Hu18Lu Zhang19Minghui Li20Minghui Li21Yao Xie22Yao Xie23Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, ChinaAimsComparison of liver histopathological findings to explore the occurrence of liver inflammation in patients with chronic hepatitis B (CHB) under different alanine aminotransferase (ALT) normal values.MethodsThe patients who were diagnosed as chronic hepatitis B virus (HBV) infection by liver histopathology at the Department of Pathology, Beijing Ditan Hospital due to clinical difficulty in defining the degree of liver inflammation or fibrosis were retrospectively enrolled from May 2008 to November 2020. Study of the incidence of significant hepatic histopathology in enrolled patients according to different ALT normal values. Using logistic regression to investigate the relevant factors of significant hepatic histopathology.ResultsA total of 1474 patients were enrolled, 56.20% of the patients were male, and the overall patients’ age was 36.80 ± 10.60 years. 39.00% of patients had liver inflammation grade G > 1, 34.70% liver fibrosis stage S > 1, and 48.17% patients had significant hepatic histopathology (G > 1 and/or S > 1). Among patients with normal ALT values, 36.40% and 40.40% had significant hepatic histopathology by American Association for the Study of Liver Diseases (AASLD) criteria and Chinese guideline criteria, respectively, but the difference was not statistically significant (χ2 =3.38, P =0.066). In contrast, among patients with abnormal ALT values, 58.90% and 62.20% of patients had significant hepatic histopathology by AASLD criteria and Chinese guideline criteria, respectively, with no significant difference (χ2 =2.28, P =0.131). ALT (P <0.001, OR=1.019), hepatitis B surface antigen (HBsAg) (P <0.001, OR=0.665) and hepatitis B e antigen (HBeAg) status (P <0.001, OR=2.238) were relevant factors in the occurrence of significant hepatic histopathology. ALT was positively corelated with grade of inflammation G (r =0.194, P <0.001) and negatively correlated with liver fibrosis stage S (r =-0.066, P =0.021).ConclusionsOur study found no statistically significant differences in the presence of significant hepatic histopathology under the two ALT criteria. ALT, HBsAg and HBeAg status were related to the occurrence of significant hepatic histopathology.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069752/fullchronic HBV-infectionALT valueHBV therapyliver histopathologyclinical indicators |
| spellingShingle | Zhan Zeng Zhan Zeng Hongxiao Hao Xiaoyue Bi Yanjie Lin Liu Yang Shiyu Wang Ge Shen Min Chang Tingting Jiang Wen Deng Huihui Lu Fangfang Sun Yao Lu Yuanjiao Gao Ruyu Liu Mengjiao Xu Xiaoxue Chen Leiping Hu Lu Zhang Minghui Li Minghui Li Yao Xie Yao Xie Study on liver histopathology of chronic HBV infected patients with different normal ALT values Frontiers in Immunology chronic HBV-infection ALT value HBV therapy liver histopathology clinical indicators |
| title | Study on liver histopathology of chronic HBV infected patients with different normal ALT values |
| title_full | Study on liver histopathology of chronic HBV infected patients with different normal ALT values |
| title_fullStr | Study on liver histopathology of chronic HBV infected patients with different normal ALT values |
| title_full_unstemmed | Study on liver histopathology of chronic HBV infected patients with different normal ALT values |
| title_short | Study on liver histopathology of chronic HBV infected patients with different normal ALT values |
| title_sort | study on liver histopathology of chronic hbv infected patients with different normal alt values |
| topic | chronic HBV-infection ALT value HBV therapy liver histopathology clinical indicators |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069752/full |
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