Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke
Background and Purpose: Post stroke reactive hyperglycemia has been associated with increased mortality and poor recovery in nondiabetic patients. Few studies have demonstrated the relationship between stress hyperglycemia and stroke outcome in Africans. A prospective study was done to evaluate the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | International Journal of Medicine and Health Development |
| Subjects: | |
| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2009;volume=14;issue=2;spage=9;epage=14;aulast=Ezeala-Adikaibe;type=0 |
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| author | B A Ezeala-Adikaibe M C Nwosu I I Ulasi |
| author_facet | B A Ezeala-Adikaibe M C Nwosu I I Ulasi |
| author_sort | B A Ezeala-Adikaibe |
| collection | DOAJ |
| description | Background and Purpose: Post stroke reactive hyperglycemia has been associated with increased mortality and poor recovery in nondiabetic patients. Few studies have demonstrated the relationship between stress hyperglycemia and stroke outcome in Africans. A prospective study was done to evaluate the prevalence of abnormal glucose metabolism in nondiabetic stroke patients and the risk of poor outcome in such patients.
Methods: Fasting plasma glucose was done after admission and patients were followed up for 30 days. Outcome was measured using the Modified Rankin scale based on the last score of each patient. Comprehensive literature search was done on relevant topics. Relative risks was calculated for plasma glucose above and below 140mg/dl.
Results: One hundred patients were recruited. Thirty-nine percent had plasma glucose levels below 110mg/dl, 15%-between110-125.9 and 12%-between126-140 while 34% above 140 mg/dl. The percentage with poor outcome corresponding to plasma glucose levels were 53.9%, 46.7%, 58.3%, 72.6% respectively. The risk of death for patients with plasma glucose above 140mg/dl was 1.116 (95% CI, 0.769-1.618), and for patients ≤140 mg/dl was 0.742 (95% CI, 0.253-2.175). A moderate positive correlation was found between Admission plasma glucose and outcome (r = 0.330, p=0.042), indicating that admission plasma glucose moderately affects outcome.
Conclusions: There was a high rate of admission hyperglycemia in nondiabetic stroke patients. Post stroke hyperglycemia predicted increased risk of poor recovery in nondiabetic stroke survivors. |
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| format | Article |
| id | doaj.art-0d6b438f6cf64f928875dc331ad93e3f |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-11T16:26:23Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-0d6b438f6cf64f928875dc331ad93e3f2022-12-22T04:14:09ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952009-01-01142914Prognostic value of admission plasma glucose in non-diabetic Nigerians with strokeB A Ezeala-AdikaibeM C NwosuI I UlasiBackground and Purpose: Post stroke reactive hyperglycemia has been associated with increased mortality and poor recovery in nondiabetic patients. Few studies have demonstrated the relationship between stress hyperglycemia and stroke outcome in Africans. A prospective study was done to evaluate the prevalence of abnormal glucose metabolism in nondiabetic stroke patients and the risk of poor outcome in such patients. Methods: Fasting plasma glucose was done after admission and patients were followed up for 30 days. Outcome was measured using the Modified Rankin scale based on the last score of each patient. Comprehensive literature search was done on relevant topics. Relative risks was calculated for plasma glucose above and below 140mg/dl. Results: One hundred patients were recruited. Thirty-nine percent had plasma glucose levels below 110mg/dl, 15%-between110-125.9 and 12%-between126-140 while 34% above 140 mg/dl. The percentage with poor outcome corresponding to plasma glucose levels were 53.9%, 46.7%, 58.3%, 72.6% respectively. The risk of death for patients with plasma glucose above 140mg/dl was 1.116 (95% CI, 0.769-1.618), and for patients ≤140 mg/dl was 0.742 (95% CI, 0.253-2.175). A moderate positive correlation was found between Admission plasma glucose and outcome (r = 0.330, p=0.042), indicating that admission plasma glucose moderately affects outcome. Conclusions: There was a high rate of admission hyperglycemia in nondiabetic stroke patients. Post stroke hyperglycemia predicted increased risk of poor recovery in nondiabetic stroke survivors.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2009;volume=14;issue=2;spage=9;epage=14;aulast=Ezeala-Adikaibe;type=0hyperglycemiapoor outcomestrokenigerians |
| spellingShingle | B A Ezeala-Adikaibe M C Nwosu I I Ulasi Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke International Journal of Medicine and Health Development hyperglycemia poor outcome stroke nigerians |
| title | Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke |
| title_full | Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke |
| title_fullStr | Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke |
| title_full_unstemmed | Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke |
| title_short | Prognostic value of admission plasma glucose in non-diabetic Nigerians with stroke |
| title_sort | prognostic value of admission plasma glucose in non diabetic nigerians with stroke |
| topic | hyperglycemia poor outcome stroke nigerians |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2009;volume=14;issue=2;spage=9;epage=14;aulast=Ezeala-Adikaibe;type=0 |
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