Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk.
<h4>Purpose</h4>Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0213624 |
| _version_ | 1818726485293268992 |
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| author | Ricardo Usategui-Martín Salvador Pastor-Idoate Antonio J Chamorro Itziar Fernández Iván Fernández-Bueno Miguel Marcos-Martín Rogelio González-Sarmiento José Carlos Pastor |
| author_facet | Ricardo Usategui-Martín Salvador Pastor-Idoate Antonio J Chamorro Itziar Fernández Iván Fernández-Bueno Miguel Marcos-Martín Rogelio González-Sarmiento José Carlos Pastor |
| author_sort | Ricardo Usategui-Martín |
| collection | DOAJ |
| description | <h4>Purpose</h4>Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.<h4>Methods</h4>We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.<h4>Results</h4>Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82-1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76-1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD.<h4>Conclusions</h4>The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility. |
| first_indexed | 2024-12-17T21:58:57Z |
| format | Article |
| id | doaj.art-0d6dc13d45ed4a8bafe4436a8d7528e3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:58:57Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0d6dc13d45ed4a8bafe4436a8d7528e32022-12-21T21:31:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01143e021362410.1371/journal.pone.0213624Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk.Ricardo Usategui-MartínSalvador Pastor-IdoateAntonio J ChamorroItziar FernándezIván Fernández-BuenoMiguel Marcos-MartínRogelio González-SarmientoJosé Carlos Pastor<h4>Purpose</h4>Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.<h4>Methods</h4>We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.<h4>Results</h4>Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82-1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76-1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD.<h4>Conclusions</h4>The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.https://doi.org/10.1371/journal.pone.0213624 |
| spellingShingle | Ricardo Usategui-Martín Salvador Pastor-Idoate Antonio J Chamorro Itziar Fernández Iván Fernández-Bueno Miguel Marcos-Martín Rogelio González-Sarmiento José Carlos Pastor Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. PLoS ONE |
| title | Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. |
| title_full | Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. |
| title_fullStr | Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. |
| title_full_unstemmed | Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. |
| title_short | Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk. |
| title_sort | meta analysis of the rs243865 mmp 2 polymorphism and age related macular degeneration risk |
| url | https://doi.org/10.1371/journal.pone.0213624 |
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