A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients
Abstract Background Various types of magnetic resonance imaging (MRI) and computed tomography (CT) findings are used to differentiate malignant vertebral fractures (MVFs) from osteoporotic vertebral fractures (OVFs). The distinguishing ability of any single finding is limited. This study developed a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12891-018-2331-0 |
| _version_ | 1818947566951202816 |
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| author | Zi Li Ming Guan Dong Sun Yong Xu Feng Li Wei Xiong |
| author_facet | Zi Li Ming Guan Dong Sun Yong Xu Feng Li Wei Xiong |
| author_sort | Zi Li |
| collection | DOAJ |
| description | Abstract Background Various types of magnetic resonance imaging (MRI) and computed tomography (CT) findings are used to differentiate malignant vertebral fractures (MVFs) from osteoporotic vertebral fractures (OVFs). The distinguishing ability of any single finding is limited. This study developed a novel scoring system that integrates multiple MRI and CT signs for improved accuracy of differential diagnosis between MVFs and OVFs. Methods A total of 150 MVFs and 150 OVFs in thoracolumbar vertebrae were analyzed. MRI and CT images were obtained within 2 months of the probable time of fracture. The sensitivity and specificity of 15 MRI and CT image findings were evaluated. A stepwise discriminant analysis using these signs as variables was used to create a scoring system to differentiate MVFs from OVFs. Results All 15 image findings had strong specificity and moderate sensitivity. Seven MRI and three CT image findings were selected and assigned integral values in the final scoring system. A total score of 4 or greater points indicated MVF, whereas a total score of 3 or fewer points indicated OVF. The classification accuracy was 98.3% in the test set. Conclusions This novel scoring system using MRI and CT radiologic findings to differentiate MVFs from OVFs in Chinese patients was efficient with high accuracy and good applicability. |
| first_indexed | 2024-12-20T08:32:57Z |
| format | Article |
| id | doaj.art-0d6f8001be8e47efae956d313fefabaa |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-20T08:32:57Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-0d6f8001be8e47efae956d313fefabaa2022-12-21T19:46:39ZengBMCBMC Musculoskeletal Disorders1471-24742018-11-011911710.1186/s12891-018-2331-0A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patientsZi Li0Ming Guan1Dong Sun2Yong Xu3Feng Li4Wei Xiong5Department of orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRadiology department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Various types of magnetic resonance imaging (MRI) and computed tomography (CT) findings are used to differentiate malignant vertebral fractures (MVFs) from osteoporotic vertebral fractures (OVFs). The distinguishing ability of any single finding is limited. This study developed a novel scoring system that integrates multiple MRI and CT signs for improved accuracy of differential diagnosis between MVFs and OVFs. Methods A total of 150 MVFs and 150 OVFs in thoracolumbar vertebrae were analyzed. MRI and CT images were obtained within 2 months of the probable time of fracture. The sensitivity and specificity of 15 MRI and CT image findings were evaluated. A stepwise discriminant analysis using these signs as variables was used to create a scoring system to differentiate MVFs from OVFs. Results All 15 image findings had strong specificity and moderate sensitivity. Seven MRI and three CT image findings were selected and assigned integral values in the final scoring system. A total score of 4 or greater points indicated MVF, whereas a total score of 3 or fewer points indicated OVF. The classification accuracy was 98.3% in the test set. Conclusions This novel scoring system using MRI and CT radiologic findings to differentiate MVFs from OVFs in Chinese patients was efficient with high accuracy and good applicability.http://link.springer.com/article/10.1186/s12891-018-2331-0Computed tomographyDiscriminant analysisMagnetic resonance imagingMalignant vertebral fractureOsteoporotic vertebral fracture |
| spellingShingle | Zi Li Ming Guan Dong Sun Yong Xu Feng Li Wei Xiong A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients BMC Musculoskeletal Disorders Computed tomography Discriminant analysis Magnetic resonance imaging Malignant vertebral fracture Osteoporotic vertebral fracture |
| title | A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients |
| title_full | A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients |
| title_fullStr | A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients |
| title_full_unstemmed | A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients |
| title_short | A novel MRI- and CT-based scoring system to differentiate malignant from osteoporotic vertebral fractures in Chinese patients |
| title_sort | novel mri and ct based scoring system to differentiate malignant from osteoporotic vertebral fractures in chinese patients |
| topic | Computed tomography Discriminant analysis Magnetic resonance imaging Malignant vertebral fracture Osteoporotic vertebral fracture |
| url | http://link.springer.com/article/10.1186/s12891-018-2331-0 |
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