NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice
Due to the idiopathic inflammation of the gastrointestinal tract and ulcerative colitis, there is an increased risk of colorectal cancer in inflammatory bowel disease (IBD) patients. Chemoprevention remains vital and much interest has been focused on targetable inflammatory proteins associated with...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617307739 |
| _version_ | 1818563182568931328 |
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| author | Nirmal Kumar Kasinathan Bharathraja Subramaniya Niranjali Devaraj Sivasithamparam |
| author_facet | Nirmal Kumar Kasinathan Bharathraja Subramaniya Niranjali Devaraj Sivasithamparam |
| author_sort | Nirmal Kumar Kasinathan |
| collection | DOAJ |
| description | Due to the idiopathic inflammation of the gastrointestinal tract and ulcerative colitis, there is an increased risk of colorectal cancer in inflammatory bowel disease (IBD) patients. Chemoprevention remains vital and much interest has been focused on targetable inflammatory proteins associated with IBD. Dextran sodium sulfate (DSS) induced colitis mimics human IBD in mouse, which is used as a model to determine the action of Lupeol (a triterpene), found in certain fruits and Indian herbs, in the healing of colitis. DSS causes chronic inflammation of the colonic epithelium by altering mucosal immune system i.e. mucins and inflammatory proteins namely TNF-α, IL 1 and 2 and NF-κB. Lupeol supplement to colitis mice, showed colonic regeneration by altering the MUC 1 & 2 gene expression. Lupeol also modulates TWIST gene expression, NF-κB, mediated inflammation and assists down regulation of TNF-α and IL genes. Thus Lupeol has potent colonic healing activity and also acts as an anti-inflammatory agent in controlling colitis. |
| first_indexed | 2024-12-14T01:13:27Z |
| format | Article |
| id | doaj.art-0d6fede093b047d887dbb1285a32770d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:13:27Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0d6fede093b047d887dbb1285a32770d2022-12-21T23:22:39ZengElsevierJournal of Functional Foods1756-46462018-02-0141240249NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in miceNirmal Kumar Kasinathan0Bharathraja Subramaniya1Niranjali Devaraj Sivasithamparam2Department of Biochemistry, School of Life Science, University of Madras, Guindy Campus, Chennai, Tamil Nadu, IndiaDepartment of Biochemistry, School of Life Science, University of Madras, Guindy Campus, Chennai, Tamil Nadu, IndiaCorresponding author.; Department of Biochemistry, School of Life Science, University of Madras, Guindy Campus, Chennai, Tamil Nadu, IndiaDue to the idiopathic inflammation of the gastrointestinal tract and ulcerative colitis, there is an increased risk of colorectal cancer in inflammatory bowel disease (IBD) patients. Chemoprevention remains vital and much interest has been focused on targetable inflammatory proteins associated with IBD. Dextran sodium sulfate (DSS) induced colitis mimics human IBD in mouse, which is used as a model to determine the action of Lupeol (a triterpene), found in certain fruits and Indian herbs, in the healing of colitis. DSS causes chronic inflammation of the colonic epithelium by altering mucosal immune system i.e. mucins and inflammatory proteins namely TNF-α, IL 1 and 2 and NF-κB. Lupeol supplement to colitis mice, showed colonic regeneration by altering the MUC 1 & 2 gene expression. Lupeol also modulates TWIST gene expression, NF-κB, mediated inflammation and assists down regulation of TNF-α and IL genes. Thus Lupeol has potent colonic healing activity and also acts as an anti-inflammatory agent in controlling colitis.http://www.sciencedirect.com/science/article/pii/S1756464617307739Aegle marmelosColitisDextran sodium sulfate (DSS)Inflammatory bowel disease (IBD)LupeolNF-κB |
| spellingShingle | Nirmal Kumar Kasinathan Bharathraja Subramaniya Niranjali Devaraj Sivasithamparam NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice Journal of Functional Foods Aegle marmelos Colitis Dextran sodium sulfate (DSS) Inflammatory bowel disease (IBD) Lupeol NF-κB |
| title | NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| title_full | NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| title_fullStr | NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| title_full_unstemmed | NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| title_short | NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| title_sort | nf κb twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice |
| topic | Aegle marmelos Colitis Dextran sodium sulfate (DSS) Inflammatory bowel disease (IBD) Lupeol NF-κB |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617307739 |
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