Icariin promotes bone marrow mesenchymal stem cells osteogenic differentiation via the mTOR/autophagy pathway to improve ketogenic diet-associated osteoporosis

Icariin promotes bone marrow mesenchymal stem cells osteogenic differentiation via the mTOR/autophagy pathway to improve ketogenic diet-associated osteoporosis

Abstract Background Icariin, a traditional Chinese medicine, has demonstrated anti-osteoporotic properties in ovariectomized mice. However, its effectiveness in preventing bone loss induced by ketogenic diet (KD), which mimics osteoporosis in human, remains unexplored. This study aims to investigate...

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Bibliographic Details
Main Authors: Wei Liu, Shouyu Xiang, Yingcong Wu, Dinghao Zhang, Chuhai Xie, Hailan Hu, Qi Liu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Icariin
mTOR
Ketogenic diet
Osteoporosis
Autophagy
Online Access:https://doi.org/10.1186/s13018-024-04529-x

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