mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells

mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells

Abstract We examined the effects of mTOR inhibitors on the fibrotic response induced by transforming growth factor-beta2 (TGF-β2) in cultured human trabecular meshwork (hTM) cells. TGF-β2-induced expression of fibronectin, collagen type I, alpha 1 chain (COL1A1), and alpha-smooth muscle actin (αSMA)...

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Bibliographic Details
Main Authors:	Nozomi Igarashi, Megumi Honjo, Makoto Aihara
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-93580-3

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