Structural biology of complement receptors
The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer. Complement receptors encompass at least eight proteins from four structural classes, orchest...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239146/full |
| _version_ | 1797688648757411840 |
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| author | Jorge Santos-López Karla de la Paz Karla de la Paz Francisco J. Fernández M. Cristina Vega |
| author_facet | Jorge Santos-López Karla de la Paz Karla de la Paz Francisco J. Fernández M. Cristina Vega |
| author_sort | Jorge Santos-López |
| collection | DOAJ |
| description | The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer. Complement receptors encompass at least eight proteins from four structural classes, orchestrating complement-mediated humoral and cellular effector responses and coordinating the complex cross-talk between innate and adaptive immunity. The progressive increase in understanding of the structural features of the main complement factors, activated proteolytic fragments, and their assemblies have spurred a renewed interest in deciphering their receptor complexes. In this review, we describe what is currently known about the structural biology of the complement receptors and their complexes with natural agonists and pharmacological antagonists. We highlight the fundamental concepts and the gray areas where issues and problems have been identified, including current research gaps. We seek to offer guidance into the structural biology of the complement system as structural information underlies fundamental and therapeutic research endeavors. Finally, we also indicate what we believe are potential developments in the field. |
| first_indexed | 2024-03-12T01:33:52Z |
| format | Article |
| id | doaj.art-0d75dd56293040a1bad7ab0c6e76312d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T01:33:52Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0d75dd56293040a1bad7ab0c6e76312d2023-09-11T10:50:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12391461239146Structural biology of complement receptorsJorge Santos-López0Karla de la Paz1Karla de la Paz2Francisco J. Fernández3M. Cristina Vega4Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, SpainCentro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, SpainResearch & Development, Abvance Biotech SL, Madrid, SpainResearch & Development, Abvance Biotech SL, Madrid, SpainCentro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, SpainThe complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer. Complement receptors encompass at least eight proteins from four structural classes, orchestrating complement-mediated humoral and cellular effector responses and coordinating the complex cross-talk between innate and adaptive immunity. The progressive increase in understanding of the structural features of the main complement factors, activated proteolytic fragments, and their assemblies have spurred a renewed interest in deciphering their receptor complexes. In this review, we describe what is currently known about the structural biology of the complement receptors and their complexes with natural agonists and pharmacological antagonists. We highlight the fundamental concepts and the gray areas where issues and problems have been identified, including current research gaps. We seek to offer guidance into the structural biology of the complement system as structural information underlies fundamental and therapeutic research endeavors. Finally, we also indicate what we believe are potential developments in the field.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239146/fullcomplementcomplement receptorsstructural biologyCR1/CR2CR3/CR4CRIg |
| spellingShingle | Jorge Santos-López Karla de la Paz Karla de la Paz Francisco J. Fernández M. Cristina Vega Structural biology of complement receptors Frontiers in Immunology complement complement receptors structural biology CR1/CR2 CR3/CR4 CRIg |
| title | Structural biology of complement receptors |
| title_full | Structural biology of complement receptors |
| title_fullStr | Structural biology of complement receptors |
| title_full_unstemmed | Structural biology of complement receptors |
| title_short | Structural biology of complement receptors |
| title_sort | structural biology of complement receptors |
| topic | complement complement receptors structural biology CR1/CR2 CR3/CR4 CRIg |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239146/full |
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