The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases
Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8824 |
| _version_ | 1797547178661511168 |
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| author | Veronika Obsilova Tomas Obsil |
| author_facet | Veronika Obsilova Tomas Obsil |
| author_sort | Veronika Obsilova |
| collection | DOAJ |
| description | Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of many kinases are regulated through protein–protein interactions, which in turn are mediated by phosphorylated motifs and often involve associations with the scaffolding and chaperon protein 14-3-3. Therefore, the aim of this review article is to provide an overview of the state of the art on 14-3-3-mediated kinase regulation, focusing on the most recent mechanistic insights into these important protein–protein interactions and discussing in detail both their structural aspects and functional consequences. |
| first_indexed | 2024-03-10T14:39:35Z |
| format | Article |
| id | doaj.art-0d75edde0b9e458288c605fc9d4ea25f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:39:35Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d75edde0b9e458288c605fc9d4ea25f2023-11-20T21:51:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122882410.3390/ijms21228824The 14-3-3 Proteins as Important Allosteric Regulators of Protein KinasesVeronika Obsilova0Tomas Obsil1Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech RepublicDepartment of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech RepublicPhosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of many kinases are regulated through protein–protein interactions, which in turn are mediated by phosphorylated motifs and often involve associations with the scaffolding and chaperon protein 14-3-3. Therefore, the aim of this review article is to provide an overview of the state of the art on 14-3-3-mediated kinase regulation, focusing on the most recent mechanistic insights into these important protein–protein interactions and discussing in detail both their structural aspects and functional consequences.https://www.mdpi.com/1422-0067/21/22/882414-3-3kinasephosphorylationRAF kinaseASK1CaMKK2 |
| spellingShingle | Veronika Obsilova Tomas Obsil The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases International Journal of Molecular Sciences 14-3-3 kinase phosphorylation RAF kinase ASK1 CaMKK2 |
| title | The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases |
| title_full | The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases |
| title_fullStr | The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases |
| title_full_unstemmed | The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases |
| title_short | The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases |
| title_sort | 14 3 3 proteins as important allosteric regulators of protein kinases |
| topic | 14-3-3 kinase phosphorylation RAF kinase ASK1 CaMKK2 |
| url | https://www.mdpi.com/1422-0067/21/22/8824 |
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