Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency
ObjectiveThe aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD).DesignSix months, double-blind, randomized, crossover, placebo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00056/full |
| _version_ | 1811270032392454144 |
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| author | Susana Gonzalez Thozhukat Sathyapalan Zeeshan Javed Stephen L. Atkin |
| author_facet | Susana Gonzalez Thozhukat Sathyapalan Zeeshan Javed Stephen L. Atkin |
| author_sort | Susana Gonzalez |
| collection | DOAJ |
| description | ObjectiveThe aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD).DesignSix months, double-blind, randomized, crossover, placebo-controlled trial of subcutaneous rGH in 17 patients with GHD.MeasurementsQuadriceps muscle biopsies were obtained at baseline, 3 months, and 6 months to measure succinate dehydrogenase (SDH) to assess mitochondrial activity. Exercise capacity was measured with cardiopulmonary exercise testing. Lipids, glycemic parameters, and body fat levels were also measured.ResultsSerum insulin-like growth factor 1 (IGF1) levels reduced fat mass by 3.2% (p < 0.05) and normalized with rGH in the active phase (p < 0.005). Patients showed an increase in SDH (p < 0.01) from base line that differed between placebo and rGH therapy treatment groups (p < 0.05): those treated by rGH followed by placebo showed a significant increase in SDH (p < 0.001) followed by a decrease, with a significant between group difference at the end of 6 months (p < 0.05). No significant improvements or correlation with exercise capacity was found.ConclusionShort-term rGH for 3 months normalized IGF1 levels, reduced fat mass, and had a significant effect on mitochondrial function, but exercise capacity was unchanged.Clinical Trial RegistrationNumber ISRCTN94165486. |
| first_indexed | 2024-04-12T21:53:39Z |
| format | Article |
| id | doaj.art-0d769be8808848eab35020c0bfa807b0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T21:53:39Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0d769be8808848eab35020c0bfa807b02022-12-22T03:15:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-02-01910.3389/fendo.2018.00056323686Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone DeficiencySusana Gonzalez0Thozhukat Sathyapalan1Zeeshan Javed2Stephen L. Atkin3Hull York Medical School, University of Hull, Heslington, United KingdomHull York Medical School, University of Hull, Heslington, United KingdomHull York Medical School, University of Hull, Heslington, United KingdomWeill Cornell Medicine Qatar, Doha, QatarObjectiveThe aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD).DesignSix months, double-blind, randomized, crossover, placebo-controlled trial of subcutaneous rGH in 17 patients with GHD.MeasurementsQuadriceps muscle biopsies were obtained at baseline, 3 months, and 6 months to measure succinate dehydrogenase (SDH) to assess mitochondrial activity. Exercise capacity was measured with cardiopulmonary exercise testing. Lipids, glycemic parameters, and body fat levels were also measured.ResultsSerum insulin-like growth factor 1 (IGF1) levels reduced fat mass by 3.2% (p < 0.05) and normalized with rGH in the active phase (p < 0.005). Patients showed an increase in SDH (p < 0.01) from base line that differed between placebo and rGH therapy treatment groups (p < 0.05): those treated by rGH followed by placebo showed a significant increase in SDH (p < 0.001) followed by a decrease, with a significant between group difference at the end of 6 months (p < 0.05). No significant improvements or correlation with exercise capacity was found.ConclusionShort-term rGH for 3 months normalized IGF1 levels, reduced fat mass, and had a significant effect on mitochondrial function, but exercise capacity was unchanged.Clinical Trial RegistrationNumber ISRCTN94165486.http://journal.frontiersin.org/article/10.3389/fendo.2018.00056/fullGH deficiencysuccinate dehydrogenasecardiovascular risk factorsexercise performancemitochondrial dysfunction |
| spellingShingle | Susana Gonzalez Thozhukat Sathyapalan Zeeshan Javed Stephen L. Atkin Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency Frontiers in Endocrinology GH deficiency succinate dehydrogenase cardiovascular risk factors exercise performance mitochondrial dysfunction |
| title | Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency |
| title_full | Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency |
| title_fullStr | Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency |
| title_full_unstemmed | Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency |
| title_short | Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency |
| title_sort | effects of growth hormone replacement on peripheral muscle and exercise capacity in severe growth hormone deficiency |
| topic | GH deficiency succinate dehydrogenase cardiovascular risk factors exercise performance mitochondrial dysfunction |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2018.00056/full |
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