The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease
Abstract Objective The study’s purpose is to explore the link of serum albumin on renal progression in patients with chronic kidney disease (CKD). Methods This study was a secondary analysis of a prospective cohort study in which a total of 954 participants were non-selectively and consecutively col...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03110-8 |
| _version_ | 1797865304710184960 |
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| author | Tong Cheng Xiaoyu Wang Yong Han Jianbing Hao Haofei Hu Lirong Hao |
| author_facet | Tong Cheng Xiaoyu Wang Yong Han Jianbing Hao Haofei Hu Lirong Hao |
| author_sort | Tong Cheng |
| collection | DOAJ |
| description | Abstract Objective The study’s purpose is to explore the link of serum albumin on renal progression in patients with chronic kidney disease (CKD). Methods This study was a secondary analysis of a prospective cohort study in which a total of 954 participants were non-selectively and consecutively collected from the research of CKD-ROUTE in Japan between November 2010 and December 2011. We evaluated the association between baseline ALB and renal prognosis (initiation of dialysis or 50% decline in eGFR from baseline) and renal function decline (annual eGFR decline) using the Cox proportional-hazards and linear regression models, respectively. We performed a number of sensitivity analyses to ensure the validity of the results. In addition, we performed subgroup analyses. Results The included patients had a mean age of (66.86 ± 13.41) years, and 522 (69.23%) were male. The mean baseline ALB and eGFR were (3.89 ± 0.59) g/dL and (33.43 ± 17.97) ml/min/1.73 m2. The annual decline in eGFR was 2.65 mL/min/1.73 m2/year. 218 (28.9%) individuals experienced renal prognosis during a median follow-up period of 36.0 months. The baseline ALB was inversely linked with renal prognosis (HR = 0.61, 95%CI: 0.45, 0.81) and renal function decline (β = -1.41, 95%CI: -2.11, -0.72) after controlling for covariates. The renal prognosis and ALB had a non-linear connection, with ALB’s inflection point occurring at 4.3 g/dL. Effect sizes (HR) were 0.42 (0.32, 0.56) and 6.11 (0.98, 38.22) on the left and right sides of the inflection point, respectively. There was also a non-linear relationship between ALB and renal function decline, and the inflection point of ALB was 4.1 g/dL. The effect sizes(β) on the left and right sides of the inflection point were -2.79(-3.62, -1.96) and 0.02 (-1.97, 1.84), respectively. Conclusion This study shows a negative and non-linear association between ALB and renal function decline as well as renal prognosis in Japanese CKD patients. When ALB is lower than 4.1 g/dL, ALB decline was closely related to poor renal prognosis and renal function decline. From a therapeutic point of view, reducing the decline in ALB makes sense for delaying CKD progression. |
| first_indexed | 2024-04-09T23:05:57Z |
| format | Article |
| id | doaj.art-0d7baf5c32bb408ca8a15f815d031e20 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-09T23:05:57Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-0d7baf5c32bb408ca8a15f815d031e202023-03-22T10:40:10ZengBMCBMC Nephrology1471-23692023-03-0124111710.1186/s12882-023-03110-8The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney diseaseTong Cheng0Xiaoyu Wang1Yong Han2Jianbing Hao3Haofei Hu4Lirong Hao5Department of Nephrology, Southern University of Science and Technology HospitalDepartment of Nephrology, Hechi People’s HospitalDepartment of Emergency, Shenzhen Second People’s HospitalDepartment of Nephrology, Southern University of Science and Technology HospitalDepartment of Nephrology, Shenzhen Second People’s HospitalDepartment of Nephrology, Southern University of Science and Technology HospitalAbstract Objective The study’s purpose is to explore the link of serum albumin on renal progression in patients with chronic kidney disease (CKD). Methods This study was a secondary analysis of a prospective cohort study in which a total of 954 participants were non-selectively and consecutively collected from the research of CKD-ROUTE in Japan between November 2010 and December 2011. We evaluated the association between baseline ALB and renal prognosis (initiation of dialysis or 50% decline in eGFR from baseline) and renal function decline (annual eGFR decline) using the Cox proportional-hazards and linear regression models, respectively. We performed a number of sensitivity analyses to ensure the validity of the results. In addition, we performed subgroup analyses. Results The included patients had a mean age of (66.86 ± 13.41) years, and 522 (69.23%) were male. The mean baseline ALB and eGFR were (3.89 ± 0.59) g/dL and (33.43 ± 17.97) ml/min/1.73 m2. The annual decline in eGFR was 2.65 mL/min/1.73 m2/year. 218 (28.9%) individuals experienced renal prognosis during a median follow-up period of 36.0 months. The baseline ALB was inversely linked with renal prognosis (HR = 0.61, 95%CI: 0.45, 0.81) and renal function decline (β = -1.41, 95%CI: -2.11, -0.72) after controlling for covariates. The renal prognosis and ALB had a non-linear connection, with ALB’s inflection point occurring at 4.3 g/dL. Effect sizes (HR) were 0.42 (0.32, 0.56) and 6.11 (0.98, 38.22) on the left and right sides of the inflection point, respectively. There was also a non-linear relationship between ALB and renal function decline, and the inflection point of ALB was 4.1 g/dL. The effect sizes(β) on the left and right sides of the inflection point were -2.79(-3.62, -1.96) and 0.02 (-1.97, 1.84), respectively. Conclusion This study shows a negative and non-linear association between ALB and renal function decline as well as renal prognosis in Japanese CKD patients. When ALB is lower than 4.1 g/dL, ALB decline was closely related to poor renal prognosis and renal function decline. From a therapeutic point of view, reducing the decline in ALB makes sense for delaying CKD progression.https://doi.org/10.1186/s12882-023-03110-8Chronic kidney diseaseSerum albuminRenal prognosisRenal function declineCox proportional hazards regression modelLinear regression model |
| spellingShingle | Tong Cheng Xiaoyu Wang Yong Han Jianbing Hao Haofei Hu Lirong Hao The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease BMC Nephrology Chronic kidney disease Serum albumin Renal prognosis Renal function decline Cox proportional hazards regression model Linear regression model |
| title | The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| title_full | The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| title_fullStr | The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| title_full_unstemmed | The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| title_short | The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| title_sort | level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease |
| topic | Chronic kidney disease Serum albumin Renal prognosis Renal function decline Cox proportional hazards regression model Linear regression model |
| url | https://doi.org/10.1186/s12882-023-03110-8 |
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