Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment
Abstract Glioblastoma (GBM) remains a formidable challenge in oncology. Chemodynamic therapy (CDT) that triggers tumor cell death by reactive oxygen species (ROS) could open up a new door for GBM treatment. Herein, we report a novel CDT nanoagent. Hemoglobin (Hb) and glucose oxidase (GOx) were emplo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-07-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s40820-020-00490-6 |
| _version_ | 1819229875515424768 |
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| author | Tao Zheng Wentao Wang Jon Ashley Ming Zhang Xiaotong Feng Jian Shen Yi Sun |
| author_facet | Tao Zheng Wentao Wang Jon Ashley Ming Zhang Xiaotong Feng Jian Shen Yi Sun |
| author_sort | Tao Zheng |
| collection | DOAJ |
| description | Abstract Glioblastoma (GBM) remains a formidable challenge in oncology. Chemodynamic therapy (CDT) that triggers tumor cell death by reactive oxygen species (ROS) could open up a new door for GBM treatment. Herein, we report a novel CDT nanoagent. Hemoglobin (Hb) and glucose oxidase (GOx) were employed as powerful CDT catalysts. Instead of encapsulating the proteins in drug delivery nanocarriers, we formulate multimeric superstructures as self-delivery entities by crosslinking techniques. Red blood cell (RBC) membranes are camouflaged on the protein superstructures to promote the delivery across blood–brain barrier. The as-prepared RBC@Hb@GOx nanoparticles (NPs) offer superior biocompatibility, simplified structure, and high accumulation at the tumor site. We successfully demonstrated that the NPs could efficiently produce toxic ROS to kill U87MG cancer cells in vitro and inhibit the growth of GBM tumor in vivo, suggesting that the new CDT nanoagent holds great promise for treating GBM. |
| first_indexed | 2024-12-23T11:20:07Z |
| format | Article |
| id | doaj.art-0d7ca1eecd1c4c14a34385cd396af97b |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-12-23T11:20:07Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-0d7ca1eecd1c4c14a34385cd396af97b2022-12-21T17:49:06ZengSpringerOpenNano-Micro Letters2311-67062150-55512020-07-0112111910.1007/s40820-020-00490-6Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma TreatmentTao Zheng0Wentao Wang1Jon Ashley2Ming Zhang3Xiaotong Feng4Jian Shen5Yi Sun6Department of Health Technology, Technical University of DenmarkDepartment of Health Technology, Technical University of DenmarkDepartment of Health Technology, Technical University of DenmarkDepartment of Health Technology, Technical University of DenmarkDepartment of Health Technology, Technical University of DenmarkJiangsu Collaborative Innovation Center for Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal UniversityDepartment of Health Technology, Technical University of DenmarkAbstract Glioblastoma (GBM) remains a formidable challenge in oncology. Chemodynamic therapy (CDT) that triggers tumor cell death by reactive oxygen species (ROS) could open up a new door for GBM treatment. Herein, we report a novel CDT nanoagent. Hemoglobin (Hb) and glucose oxidase (GOx) were employed as powerful CDT catalysts. Instead of encapsulating the proteins in drug delivery nanocarriers, we formulate multimeric superstructures as self-delivery entities by crosslinking techniques. Red blood cell (RBC) membranes are camouflaged on the protein superstructures to promote the delivery across blood–brain barrier. The as-prepared RBC@Hb@GOx nanoparticles (NPs) offer superior biocompatibility, simplified structure, and high accumulation at the tumor site. We successfully demonstrated that the NPs could efficiently produce toxic ROS to kill U87MG cancer cells in vitro and inhibit the growth of GBM tumor in vivo, suggesting that the new CDT nanoagent holds great promise for treating GBM.http://link.springer.com/article/10.1007/s40820-020-00490-6Self-assembly protein superstructuresGlioblastoma therapyChemodynamic therapySelf-delivery entitiesBlood–brain barrier |
| spellingShingle | Tao Zheng Wentao Wang Jon Ashley Ming Zhang Xiaotong Feng Jian Shen Yi Sun Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment Nano-Micro Letters Self-assembly protein superstructures Glioblastoma therapy Chemodynamic therapy Self-delivery entities Blood–brain barrier |
| title | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment |
| title_full | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment |
| title_fullStr | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment |
| title_full_unstemmed | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment |
| title_short | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment |
| title_sort | self assembly protein superstructures as a powerful chemodynamic therapy nanoagent for glioblastoma treatment |
| topic | Self-assembly protein superstructures Glioblastoma therapy Chemodynamic therapy Self-delivery entities Blood–brain barrier |
| url | http://link.springer.com/article/10.1007/s40820-020-00490-6 |
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