Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection
Pyoderma gangrenosum (PG) is a rare and chronic neutrophil inflammation belonging to the spectrum of autoinflammatory disorders. Immunosuppressive therapy is the cornerstone of successful treatment. However, due to the global COVID-19 pandemic, physicians struggle with therapeutic strategies during...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/2/173 |
| _version_ | 1797478814088953856 |
|---|---|
| author | Marcella Ricardis May Albert Rübben Andrea Lennertz Luk Vanstreels Marike Leijs |
| author_facet | Marcella Ricardis May Albert Rübben Andrea Lennertz Luk Vanstreels Marike Leijs |
| author_sort | Marcella Ricardis May |
| collection | DOAJ |
| description | Pyoderma gangrenosum (PG) is a rare and chronic neutrophil inflammation belonging to the spectrum of autoinflammatory disorders. Immunosuppressive therapy is the cornerstone of successful treatment. However, due to the global COVID-19 pandemic, physicians struggle with therapeutic strategies during infection. This paper describes the case of a 58-year-old patient with a very painful, rapidly increasing wound on his right foot, which was diagnosed as pyoderma gangrenosum. Five weeks after the initial treatment with high-dose immunosuppressives (combination therapy with cyclosporine A and systemic methylprednisolone), he became infected with COVID-19. Reduction in the immunosuppressive dosage proved effective, as the patient recovered from COVID-19 without any complication and showed rapid wound healing. |
| first_indexed | 2024-03-09T21:36:55Z |
| format | Article |
| id | doaj.art-0d7d1e9d8e354b6a801f426fcade18a2 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T21:36:55Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-0d7d1e9d8e354b6a801f426fcade18a22023-11-23T20:39:22ZengMDPI AGJournal of Personalized Medicine2075-44262022-01-0112217310.3390/jpm12020173Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 InfectionMarcella Ricardis May0Albert Rübben1Andrea Lennertz2Luk Vanstreels3Marike Leijs4Department of Dermatology and Allergology, University Hospital of the RWTH Aachen University, 52074 Aachen, GermanyDepartment of Dermatology and Allergology, University Hospital of the RWTH Aachen University, 52074 Aachen, GermanyDepartment of Internal Medicine, St. Nikolaus Hospital, 4700 Eupen, BelgiumDepartment of Dermatology, St. Nikolaus Hospital, 4700 Eupen, BelgiumDepartment of Dermatology and Allergology, University Hospital of the RWTH Aachen University, 52074 Aachen, GermanyPyoderma gangrenosum (PG) is a rare and chronic neutrophil inflammation belonging to the spectrum of autoinflammatory disorders. Immunosuppressive therapy is the cornerstone of successful treatment. However, due to the global COVID-19 pandemic, physicians struggle with therapeutic strategies during infection. This paper describes the case of a 58-year-old patient with a very painful, rapidly increasing wound on his right foot, which was diagnosed as pyoderma gangrenosum. Five weeks after the initial treatment with high-dose immunosuppressives (combination therapy with cyclosporine A and systemic methylprednisolone), he became infected with COVID-19. Reduction in the immunosuppressive dosage proved effective, as the patient recovered from COVID-19 without any complication and showed rapid wound healing.https://www.mdpi.com/2075-4426/12/2/173COVID-19pyoderma gangrenosumimmunosuppressioncyclosporinecorticosteroidsautoinflammatory disease |
| spellingShingle | Marcella Ricardis May Albert Rübben Andrea Lennertz Luk Vanstreels Marike Leijs Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection Journal of Personalized Medicine COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease |
| title | Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection |
| title_full | Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection |
| title_fullStr | Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection |
| title_full_unstemmed | Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection |
| title_short | Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 Infection |
| title_sort | dealing with corticosteroid and high dose cyclosporine therapy in a pyoderma gangrenosum patient contracting a covid 19 infection |
| topic | COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease |
| url | https://www.mdpi.com/2075-4426/12/2/173 |
| work_keys_str_mv | AT marcellaricardismay dealingwithcorticosteroidandhighdosecyclosporinetherapyinapyodermagangrenosumpatientcontractingacovid19infection AT albertrubben dealingwithcorticosteroidandhighdosecyclosporinetherapyinapyodermagangrenosumpatientcontractingacovid19infection AT andrealennertz dealingwithcorticosteroidandhighdosecyclosporinetherapyinapyodermagangrenosumpatientcontractingacovid19infection AT lukvanstreels dealingwithcorticosteroidandhighdosecyclosporinetherapyinapyodermagangrenosumpatientcontractingacovid19infection AT marikeleijs dealingwithcorticosteroidandhighdosecyclosporinetherapyinapyodermagangrenosumpatientcontractingacovid19infection |