Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast

Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast

Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene function. Here, we describe a generic approach using the yeast S...

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Bibliographic Details
Main Authors: Barry P. Young, Kathryn L. Post, Jesse T. Chao, Fabian Meili, Kurt Haas, Christopher Loewen
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Disease Models & Mechanisms
Subjects:
yeast
variants
human disease genes
Online Access:http://dmm.biologists.org/content/13/7/dmm044560

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