NETosis in Wound Healing: When Enough Is Enough
The neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism,...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/494 |
| _version_ | 1797395276920520704 |
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| author | Maurizio Sabbatini Valeria Magnelli Filippo Renò |
| author_facet | Maurizio Sabbatini Valeria Magnelli Filippo Renò |
| author_sort | Maurizio Sabbatini |
| collection | DOAJ |
| description | The neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now considered an extreme defensive solution, which in particular situations induces strong negative effects on tissue physiology, causing or exacerbating pathologies as recently shown in NETs-mediated organ damage in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial activity, while the negative effects appear to be more common in a plethora of pathological conditions (such as diabetes) and linked to a NETosis upregulation. Recent evidence suggests there are other positive physiological NETs effects on wound healing that are worthy of a broader research effort. |
| first_indexed | 2024-03-09T00:32:09Z |
| format | Article |
| id | doaj.art-0d7f2e39c45f44578aa32ac2ab8b8ab3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T00:32:09Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0d7f2e39c45f44578aa32ac2ab8b8ab32023-12-11T18:24:26ZengMDPI AGCells2073-44092021-02-0110349410.3390/cells10030494NETosis in Wound Healing: When Enough Is EnoughMaurizio Sabbatini0Valeria Magnelli1Filippo Renò2Department of Science and Innovation Technology (DISIT), Università del Piemonte Orientale—via T. Michel 11, 15121 Alessandria, ItalyDepartment of Science and Innovation Technology (DISIT), Università del Piemonte Orientale—via T. Michel 11, 15121 Alessandria, ItalyInnovative Research Laboratory for Wound Healing, Health Sciences Department, Università del Piemonte Orientale, via Solaroli 17, 28100 Novara, ItalyThe neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now considered an extreme defensive solution, which in particular situations induces strong negative effects on tissue physiology, causing or exacerbating pathologies as recently shown in NETs-mediated organ damage in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial activity, while the negative effects appear to be more common in a plethora of pathological conditions (such as diabetes) and linked to a NETosis upregulation. Recent evidence suggests there are other positive physiological NETs effects on wound healing that are worthy of a broader research effort.https://www.mdpi.com/2073-4409/10/3/494netosiswound healinginflammationinnate immunity |
| spellingShingle | Maurizio Sabbatini Valeria Magnelli Filippo Renò NETosis in Wound Healing: When Enough Is Enough Cells netosis wound healing inflammation innate immunity |
| title | NETosis in Wound Healing: When Enough Is Enough |
| title_full | NETosis in Wound Healing: When Enough Is Enough |
| title_fullStr | NETosis in Wound Healing: When Enough Is Enough |
| title_full_unstemmed | NETosis in Wound Healing: When Enough Is Enough |
| title_short | NETosis in Wound Healing: When Enough Is Enough |
| title_sort | netosis in wound healing when enough is enough |
| topic | netosis wound healing inflammation innate immunity |
| url | https://www.mdpi.com/2073-4409/10/3/494 |
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