TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS
This article contains results of the research of tocilizumab treatment efficacy and safety in 39 patients with severe systemic juvenile idiopathic arthritis, resistant to standard immunosuppressive treatment. Tocilizumab efficacy analysis has shown 50% of patients with inactive disease after 6 month...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2011-05-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/608 |
| _version_ | 1826562084062625792 |
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| author | E.I. Alexeeva R.V. Denisova S.I. Valieva T.M. Bzarova K.B. Isaeva E.G. Chistyakova T.V. Sleptsova E.V. Mitenko |
| author_facet | E.I. Alexeeva R.V. Denisova S.I. Valieva T.M. Bzarova K.B. Isaeva E.G. Chistyakova T.V. Sleptsova E.V. Mitenko |
| author_sort | E.I. Alexeeva |
| collection | DOAJ |
| description | This article contains results of the research of tocilizumab treatment efficacy and safety in 39 patients with severe systemic juvenile idiopathic arthritis, resistant to standard immunosuppressive treatment. Tocilizumab efficacy analysis has shown 50% of patients with inactive disease after 6 months of treatment, and 57% of patients with inactive disease after 12 months. Among adverse events were mild and moderate infections and such laboratory abnormalities as low leukocyte and neutrophiles count.Key words: children, juvenile idiopathic arthritis, systemic arthritis, tocilizumab, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 24–32) |
| first_indexed | 2024-03-12T04:53:28Z |
| format | Article |
| id | doaj.art-0d82507362104b2995c6cbb28e9af55b |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:42:26Z |
| publishDate | 2011-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-0d82507362104b2995c6cbb28e9af55b2025-03-02T11:34:01Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352011-05-01103608TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITISE.I. Alexeeva0R.V. Denisova1S.I. Valieva2T.M. Bzarova3K.B. Isaeva4E.G. Chistyakova5T.V. Sleptsova6E.V. Mitenko7Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow I.M. Sechenov First Moscow State Medical UniversityScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow I.M. Sechenov First Moscow State Medical UniversityScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowThis article contains results of the research of tocilizumab treatment efficacy and safety in 39 patients with severe systemic juvenile idiopathic arthritis, resistant to standard immunosuppressive treatment. Tocilizumab efficacy analysis has shown 50% of patients with inactive disease after 6 months of treatment, and 57% of patients with inactive disease after 12 months. Among adverse events were mild and moderate infections and such laboratory abnormalities as low leukocyte and neutrophiles count.Key words: children, juvenile idiopathic arthritis, systemic arthritis, tocilizumab, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 24–32)https://vsp.spr-journal.ru/jour/article/view/608 |
| spellingShingle | E.I. Alexeeva R.V. Denisova S.I. Valieva T.M. Bzarova K.B. Isaeva E.G. Chistyakova T.V. Sleptsova E.V. Mitenko TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS Вопросы современной педиатрии |
| title | TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_full | TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_fullStr | TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_short | TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_sort | tocilizumab efficacy and safety in patients with severe systemic juvenile idiopathic arthritis |
| url | https://vsp.spr-journal.ru/jour/article/view/608 |
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