HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis
Objectives Lower high-density lipoprotein cholesterol (HDL-C) levels have been observed in chronic liver disease patients. The aim of this study was to develop a model that incorporates HDL-C levels and the Model for End-stage Liver Disease (MELD) score to predict 30-day mortality in Asian cirrhosis...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221109385 |
| _version_ | 1828542686055890944 |
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| author | Yue Wang Wenjuan Shen Fang Huang Chenyan Yu Liting Xi Jingwen Gao Minyue Yin Xiaolin Liu Jiaxi Lin Lu Liu Huixian Zhang Jinzhou Zhu Yu Hong |
| author_facet | Yue Wang Wenjuan Shen Fang Huang Chenyan Yu Liting Xi Jingwen Gao Minyue Yin Xiaolin Liu Jiaxi Lin Lu Liu Huixian Zhang Jinzhou Zhu Yu Hong |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Objectives Lower high-density lipoprotein cholesterol (HDL-C) levels have been observed in chronic liver disease patients. The aim of this study was to develop a model that incorporates HDL-C levels and the Model for End-stage Liver Disease (MELD) score to predict 30-day mortality in Asian cirrhosis patients. Methods Cirrhosis patients were recruited from two hospitals in this retrospective observational study. Propensity score matching was used. The model’s performance was evaluated, including its ability to predict 30-day mortality, accuracy, and clinical utility. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated. Results The HDL-C + MELD model showed good ability to predict 30-day mortality (area under the curve, 0.784; sensitivity, 0.797; specificity, 0.632), which was better than that of the MELD score alone. It also showed good calibration and a net benefit for all patients, which was better than that of the MELD score, except at the threshold probability. NRI and IDI results confirmed that adding HDL-C levels to the MELD score improved the model’s performance in predicting 30-day mortality. Conclusion We added HDL-C levels to the MELD score to predict 30-day mortality in Asian patients with cirrhosis. The HDLC + MELD model shows good ability to predict 30-day mortality and clinical utility. |
| first_indexed | 2024-12-12T02:01:28Z |
| format | Article |
| id | doaj.art-0d836f641ed04ed2b232a6020d106c14 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-12T02:01:28Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-0d836f641ed04ed2b232a6020d106c142022-12-22T00:42:10ZengSAGE PublishingJournal of International Medical Research1473-23002022-07-015010.1177/03000605221109385HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosisYue WangWenjuan ShenFang HuangChenyan YuLiting XiJingwen GaoMinyue YinXiaolin LiuJiaxi LinLu LiuHuixian ZhangJinzhou ZhuYu HongObjectives Lower high-density lipoprotein cholesterol (HDL-C) levels have been observed in chronic liver disease patients. The aim of this study was to develop a model that incorporates HDL-C levels and the Model for End-stage Liver Disease (MELD) score to predict 30-day mortality in Asian cirrhosis patients. Methods Cirrhosis patients were recruited from two hospitals in this retrospective observational study. Propensity score matching was used. The model’s performance was evaluated, including its ability to predict 30-day mortality, accuracy, and clinical utility. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated. Results The HDL-C + MELD model showed good ability to predict 30-day mortality (area under the curve, 0.784; sensitivity, 0.797; specificity, 0.632), which was better than that of the MELD score alone. It also showed good calibration and a net benefit for all patients, which was better than that of the MELD score, except at the threshold probability. NRI and IDI results confirmed that adding HDL-C levels to the MELD score improved the model’s performance in predicting 30-day mortality. Conclusion We added HDL-C levels to the MELD score to predict 30-day mortality in Asian patients with cirrhosis. The HDLC + MELD model shows good ability to predict 30-day mortality and clinical utility.https://doi.org/10.1177/03000605221109385 |
| spellingShingle | Yue Wang Wenjuan Shen Fang Huang Chenyan Yu Liting Xi Jingwen Gao Minyue Yin Xiaolin Liu Jiaxi Lin Lu Liu Huixian Zhang Jinzhou Zhu Yu Hong HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis Journal of International Medical Research |
| title | HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis |
| title_full | HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis |
| title_fullStr | HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis |
| title_full_unstemmed | HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis |
| title_short | HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis |
| title_sort | hdl c levels added to the meld score improves 30 day mortality prediction in asian patients with cirrhosis |
| url | https://doi.org/10.1177/03000605221109385 |
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