Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report
Abstract Background Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04086-7 |
| _version_ | 1797452492098764800 |
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| author | Mohammad Sistanizad Tahereh Sabaghian Hossein Amini Fahimeh Hadavand Mahmood Nabavi Mehran Kouchek Mir Mohammad Miri Sara Salarian Seyedpouzhia Shojaei Omid Moradi |
| author_facet | Mohammad Sistanizad Tahereh Sabaghian Hossein Amini Fahimeh Hadavand Mahmood Nabavi Mehran Kouchek Mir Mohammad Miri Sara Salarian Seyedpouzhia Shojaei Omid Moradi |
| author_sort | Mohammad Sistanizad |
| collection | DOAJ |
| description | Abstract Background Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenting the first case of vaccine-induced thrombotic thrombocytopenia with this type of vaccine. Case presentation An 18-year-old male Caucasian patient with complaints of severe abdominal, low back, and lower extremity pain presented to the medical center. He received the first dose of the Sinopharm (HB02) vaccine against coronavirus disease 2019 10 days before hospital attendance. In the laboratory examination, decreased platelet count and increased D-dimer were observed. During hospital admission, the diagnosis of pulmonary embolism was reached. He received vaccine-induced thrombotic thrombocytopenia therapy consisting of intravenous immune globulin and direct oral anticoagulant. Platelet count increased and he was discharged after 1 month. Conclusion This case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered. |
| first_indexed | 2024-03-09T15:09:27Z |
| format | Article |
| id | doaj.art-0d83d0ac54c44340a6b698594db76c86 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-09T15:09:27Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-0d83d0ac54c44340a6b698594db76c862023-11-26T13:25:44ZengBMCJournal of Medical Case Reports1752-19472023-09-011711510.1186/s13256-023-04086-7Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case reportMohammad Sistanizad0Tahereh Sabaghian1Hossein Amini2Fahimeh Hadavand3Mahmood Nabavi4Mehran Kouchek5Mir Mohammad Miri6Sara Salarian7Seyedpouzhia Shojaei8Omid Moradi9Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical SciencesDivision of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical SciencesDepartment of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Imam Hossein Teaching and Medical Center, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Imam Hossein Teaching and Medical Center, Shahid Beheshti University of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Imam Hossein Teaching and Educational Center, Shahid Beheshti University of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Imam Hossein Teaching and Educational Center, Shahid Beheshti University of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Imam Hossein Teaching and Educational Center, Shahid Beheshti University of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Imam Hossein Teaching and Educational Center, Shahid Beheshti University of Medical SciencesDepartment of Clinical Pharmacy, Faculty of Pharmacy, Hormozgan University of Medical SciencesAbstract Background Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenting the first case of vaccine-induced thrombotic thrombocytopenia with this type of vaccine. Case presentation An 18-year-old male Caucasian patient with complaints of severe abdominal, low back, and lower extremity pain presented to the medical center. He received the first dose of the Sinopharm (HB02) vaccine against coronavirus disease 2019 10 days before hospital attendance. In the laboratory examination, decreased platelet count and increased D-dimer were observed. During hospital admission, the diagnosis of pulmonary embolism was reached. He received vaccine-induced thrombotic thrombocytopenia therapy consisting of intravenous immune globulin and direct oral anticoagulant. Platelet count increased and he was discharged after 1 month. Conclusion This case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered.https://doi.org/10.1186/s13256-023-04086-7COVID-19VaccineThrombosisWhole-virus vaccineCase report |
| spellingShingle | Mohammad Sistanizad Tahereh Sabaghian Hossein Amini Fahimeh Hadavand Mahmood Nabavi Mehran Kouchek Mir Mohammad Miri Sara Salarian Seyedpouzhia Shojaei Omid Moradi Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report Journal of Medical Case Reports COVID-19 Vaccine Thrombosis Whole-virus vaccine Case report |
| title | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
| title_full | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
| title_fullStr | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
| title_full_unstemmed | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
| title_short | Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report |
| title_sort | sinopharm hb02 associated vaccine induced immune thrombotic thrombocytopenia a case report |
| topic | COVID-19 Vaccine Thrombosis Whole-virus vaccine Case report |
| url | https://doi.org/10.1186/s13256-023-04086-7 |
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