The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent
Fluoroquinolones (FQs) are broad-spectrum antibiotics widely used to treat animal and human infections. The use of FQs in these activities has increased the presence of antibiotics in wastewater and food, triggering antimicrobial resistance, which has severe consequences for human health. The detect...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8120 |
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| author | A. N. Baeza Idoia Urriza-Arsuaga F. Navarro-Villoslada Javier L. Urraca |
| author_facet | A. N. Baeza Idoia Urriza-Arsuaga F. Navarro-Villoslada Javier L. Urraca |
| author_sort | A. N. Baeza |
| collection | DOAJ |
| description | Fluoroquinolones (FQs) are broad-spectrum antibiotics widely used to treat animal and human infections. The use of FQs in these activities has increased the presence of antibiotics in wastewater and food, triggering antimicrobial resistance, which has severe consequences for human health. The detection of antibiotics residues in water and food samples has attracted much attention. Herein, we report the development of a highly sensitive online solid-phase extraction methodology based on a selective molecularly imprinted polymer (MIP) and fluorescent detection (HPLC-FLD) for the determination of FQs in water at low ng L<sup>−1</sup> level concentration. Under the optimal conditions, good linearity was obtained ranging from 0.7 to 666 ng L<sup>−1</sup> for 7 FQs, achieving limits of detection (LOD) in the low ng L<sup>−1</sup> level and excellent precision. Recoveries ranged between 54 and 118% (RSD < 17%) for all the FQs tested. The method was applied to determining FQs in river water. These results demonstrated that the developed method is highly sensitive and selective. |
| first_indexed | 2024-03-09T17:40:19Z |
| format | Article |
| id | doaj.art-0d8409af83454a6cbc69ae9ad82e6e9f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:40:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0d8409af83454a6cbc69ae9ad82e6e9f2023-11-24T11:36:57ZengMDPI AGMolecules1420-30492022-11-012723812010.3390/molecules27238120The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective SorbentA. N. Baeza0Idoia Urriza-Arsuaga1F. Navarro-Villoslada2Javier L. Urraca3Institute of Science and Technology of Materials, University of Havana, Zapata y G, La Habana 10400, CubaIndependent Researcher, 28007 Madrid, SpainDepartment of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Plaza Ciencias, 2, 28040 Madrid, SpainDepartment of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Plaza Ciencias, 2, 28040 Madrid, SpainFluoroquinolones (FQs) are broad-spectrum antibiotics widely used to treat animal and human infections. The use of FQs in these activities has increased the presence of antibiotics in wastewater and food, triggering antimicrobial resistance, which has severe consequences for human health. The detection of antibiotics residues in water and food samples has attracted much attention. Herein, we report the development of a highly sensitive online solid-phase extraction methodology based on a selective molecularly imprinted polymer (MIP) and fluorescent detection (HPLC-FLD) for the determination of FQs in water at low ng L<sup>−1</sup> level concentration. Under the optimal conditions, good linearity was obtained ranging from 0.7 to 666 ng L<sup>−1</sup> for 7 FQs, achieving limits of detection (LOD) in the low ng L<sup>−1</sup> level and excellent precision. Recoveries ranged between 54 and 118% (RSD < 17%) for all the FQs tested. The method was applied to determining FQs in river water. These results demonstrated that the developed method is highly sensitive and selective.https://www.mdpi.com/1420-3049/27/23/8120molecularly imprinted polymersfluoroquinolonessolid phase extractiononline SPEwater samples |
| spellingShingle | A. N. Baeza Idoia Urriza-Arsuaga F. Navarro-Villoslada Javier L. Urraca The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent Molecules molecularly imprinted polymers fluoroquinolones solid phase extraction online SPE water samples |
| title | The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent |
| title_full | The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent |
| title_fullStr | The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent |
| title_full_unstemmed | The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent |
| title_short | The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent |
| title_sort | ultratrace determination of fluoroquinolones in river water samples by an online solid phase extraction method using a molecularly imprinted polymer as a selective sorbent |
| topic | molecularly imprinted polymers fluoroquinolones solid phase extraction online SPE water samples |
| url | https://www.mdpi.com/1420-3049/27/23/8120 |
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