Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility
Background: Azoospermia is a highly evolving subject in the last few decades. In the past, use of donor sperm was the only option providing a realistic chance of conception for couples affected by azoospermia. Introduction of sperm retrieval techniques and assisted reproductive technologies, especia...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2020;volume=13;issue=3;spage=201;epage=208;aulast=Talreja |
| _version_ | 1818218356377911296 |
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| author | Deepa Talreja Chirag Gupta Hrishikesh Pai Nandita Palshetkar Rupin Shah |
| author_facet | Deepa Talreja Chirag Gupta Hrishikesh Pai Nandita Palshetkar Rupin Shah |
| author_sort | Deepa Talreja |
| collection | DOAJ |
| description | Background: Azoospermia is a highly evolving subject in the last few decades. In the past, use of donor sperm was the only option providing a realistic chance of conception for couples affected by azoospermia. Introduction of sperm retrieval techniques and assisted reproductive technologies, especially intracytoplasmic sperm injection (ICSI), has provided these men a chance to father their genetically own child and changed the management approach significantly. Objective: The objective was to compare the sperm retrieval rate (SRR) and ICSI outcomes of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia (NOA) as well as to evaluate the efficacy of sperm retrieval techniques. Materials and Methods: A total of sixty azoospermic patients were included in the study. The patients were divided between OA (16) and NOA groups (44). A retrospective outcome analysis was done on SRR and ICSI results among them. Results: The overall SRR in patients with NOA and OA was 47.7% and 100%, respectively (P < 0.001). On subgroup analysis, higher serum follicle-stimulating hormone has shown significantly decreased sperm retrieval. The size of testes was not found to be related to sperm retrieval. Fertilization and embryo formation rate were found to be higher in OA cases in comparison to those of NOA cases. Clinical pregnancy rate showed no significant difference. Conclusion: Various sperm retrieval techniques can provide new dimensions for successful ICSI and managing azoospermia patients. Although SRRs as well as ICSI outcomes are lower in NOA patients than patients with OA, still they are potentially fertile. A systematic approach especially in patients with NOA is an important step. Microdissection testicular sperm extraction is an attractive option for NOA patients in order to increase the chances of successful sperm retrieval. |
| first_indexed | 2024-12-12T07:22:28Z |
| format | Article |
| id | doaj.art-0d8703c1e116408cace14d657a2b9762 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-12T07:22:28Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-0d8703c1e116408cace14d657a2b97622022-12-22T00:33:17ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662020-01-0113320120810.4103/jhrs.JHRS_41_19Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertilityDeepa TalrejaChirag GuptaHrishikesh PaiNandita PalshetkarRupin ShahBackground: Azoospermia is a highly evolving subject in the last few decades. In the past, use of donor sperm was the only option providing a realistic chance of conception for couples affected by azoospermia. Introduction of sperm retrieval techniques and assisted reproductive technologies, especially intracytoplasmic sperm injection (ICSI), has provided these men a chance to father their genetically own child and changed the management approach significantly. Objective: The objective was to compare the sperm retrieval rate (SRR) and ICSI outcomes of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia (NOA) as well as to evaluate the efficacy of sperm retrieval techniques. Materials and Methods: A total of sixty azoospermic patients were included in the study. The patients were divided between OA (16) and NOA groups (44). A retrospective outcome analysis was done on SRR and ICSI results among them. Results: The overall SRR in patients with NOA and OA was 47.7% and 100%, respectively (P < 0.001). On subgroup analysis, higher serum follicle-stimulating hormone has shown significantly decreased sperm retrieval. The size of testes was not found to be related to sperm retrieval. Fertilization and embryo formation rate were found to be higher in OA cases in comparison to those of NOA cases. Clinical pregnancy rate showed no significant difference. Conclusion: Various sperm retrieval techniques can provide new dimensions for successful ICSI and managing azoospermia patients. Although SRRs as well as ICSI outcomes are lower in NOA patients than patients with OA, still they are potentially fertile. A systematic approach especially in patients with NOA is an important step. Microdissection testicular sperm extraction is an attractive option for NOA patients in order to increase the chances of successful sperm retrieval.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2020;volume=13;issue=3;spage=201;epage=208;aulast=Talrejafertilization ratenonobstructive azoospermiareproductive outcomessperm retrieval |
| spellingShingle | Deepa Talreja Chirag Gupta Hrishikesh Pai Nandita Palshetkar Rupin Shah Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility Journal of Human Reproductive Sciences fertilization rate nonobstructive azoospermia reproductive outcomes sperm retrieval |
| title | Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| title_full | Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| title_fullStr | Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| title_full_unstemmed | Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| title_short | Comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| title_sort | comparative analysis of surgically retrieved sperms in cases of obstructive and nonobstructive azoospermia treated for infertility |
| topic | fertilization rate nonobstructive azoospermia reproductive outcomes sperm retrieval |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2020;volume=13;issue=3;spage=201;epage=208;aulast=Talreja |
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