Delta-tocotrienol disrupts PD-L1 glycosylation and reverses PD-L1-mediated immune suppression

Delta-tocotrienol disrupts PD-L1 glycosylation and reverses PD-L1-mediated immune suppression

PD-L1-mediated immune escape plays an important role in cancer development and progression. Targeting PD-L1 is consider to be an attractive approach for cancer treatment. PD-L1 is a heavily N-linked glycosylated protein, and the glycosylation of PD-L1 is essential for its ability to interact with it...

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Bibliographic Details
Main Authors: Zhenou Sun, Xuan Ma, Chong Zhao, Lihong Fan, Shutao Yin, Hongbo Hu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Vitamin E
δ-tocotrienol
PD-L1
Glycosylation
Immune suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223018760

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http://www.sciencedirect.com/science/article/pii/S0753332223018760

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