Downregulation of COL12A1 and COL13A1 by a selective EP2 receptor agonist, omidenepag, in human trabecular meshwork cells

Downregulation of COL12A1 and COL13A1 by a selective EP2 receptor agonist, omidenepag, in human trabecular meshwork cells

Omidenepag isopropyl (OMDI) is an intraocular pressure (IOP)-lowering drug used to treat glaucoma. The active form of OMDI, omidenepag (OMD), lowers elevated IOP, the main risk factor for glaucoma, by increasing the aqueous humor outflow; however, a detailed understanding of this mechanism is lackin...

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Bibliographic Details
Main Authors: Masashi Kumon, Masahiro Fuwa, Atsushi Shimazaki, Noriko Odani-Kawabata, Ryo Iwamura, Kenji Yoneda, Masatomo Kato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833537/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833537/?tool=EBI

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