Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology
Aim. To comparatively analyze the clinical efficiency of eradiation therapy (ET) in patients with coronary heart disease (CHD) concurrent with gastroduodenal pathology (GDP). Subjects and methods. The study was conducted in three steps. In Step 1, 1588 patients with chronic CHD were examined. In Ste...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2017-08-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32275/pdf |
| _version_ | 1818466634091724800 |
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| author | Zh G Simonova A K Martusevich E I Tarlovskaya |
| author_facet | Zh G Simonova A K Martusevich E I Tarlovskaya |
| author_sort | Zh G Simonova |
| collection | DOAJ |
| description | Aim. To comparatively analyze the clinical efficiency of eradiation therapy (ET) in patients with coronary heart disease (CHD) concurrent with gastroduodenal pathology (GDP). Subjects and methods. The study was conducted in three steps. In Step 1, 1588 patients with chronic CHD were examined. In Step 2, the characteristics of the course of CHD concurrent with Helicobacter pylori-associated GDP in 147 patients with these conditions compared to the same number of CHD patients without GDP. In Step 3, the impact of a GDP treatment option on the efficiency of treatment was investigated in the patients with CHD. Group 1 received ET + basic therapy (BT); Group 2 used antisecretory therapy + BT; Group 3 consisted of CHD patients without concomitant GDP who received BT only. The time course of changes in clinical and quality-of-life (QOL) indicators was assessed. Results. The patients with CHD concurrent with GDP have a more severe course of the disease as manifested by deterioration in clinical status and QOL. After ET, anginal attack rates were decreased by 62.6% in Group 1, by 30.7% in Group 2 (during antisecretory therapy), and by 29.5% in Group 3. The level of physical QOL increased by 23.7% in Group 1, which was not observed in Groups 2 and 3. Conclusion. Inclusion of ET in an algorithm for treating CHD patients with GDP promotes the angina stability and normalizes QOL in the patients. |
| first_indexed | 2024-04-13T21:00:36Z |
| format | Article |
| id | doaj.art-0d8a1aabdbaf4ac18d4bfc4d179efb6b |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-13T21:00:36Z |
| publishDate | 2017-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-0d8a1aabdbaf4ac18d4bfc4d179efb6b2022-12-22T02:30:09Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422017-08-01898374210.17116/terarkh201789837-4229275Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathologyZh G SimonovaA K MartusevichE I TarlovskayaAim. To comparatively analyze the clinical efficiency of eradiation therapy (ET) in patients with coronary heart disease (CHD) concurrent with gastroduodenal pathology (GDP). Subjects and methods. The study was conducted in three steps. In Step 1, 1588 patients with chronic CHD were examined. In Step 2, the characteristics of the course of CHD concurrent with Helicobacter pylori-associated GDP in 147 patients with these conditions compared to the same number of CHD patients without GDP. In Step 3, the impact of a GDP treatment option on the efficiency of treatment was investigated in the patients with CHD. Group 1 received ET + basic therapy (BT); Group 2 used antisecretory therapy + BT; Group 3 consisted of CHD patients without concomitant GDP who received BT only. The time course of changes in clinical and quality-of-life (QOL) indicators was assessed. Results. The patients with CHD concurrent with GDP have a more severe course of the disease as manifested by deterioration in clinical status and QOL. After ET, anginal attack rates were decreased by 62.6% in Group 1, by 30.7% in Group 2 (during antisecretory therapy), and by 29.5% in Group 3. The level of physical QOL increased by 23.7% in Group 1, which was not observed in Groups 2 and 3. Conclusion. Inclusion of ET in an algorithm for treating CHD patients with GDP promotes the angina stability and normalizes QOL in the patients.https://ter-arkhiv.ru/0040-3660/article/viewFile/32275/pdfcoronary heart diseasegastroduodenal pathologyeradication therapy |
| spellingShingle | Zh G Simonova A K Martusevich E I Tarlovskaya Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology Терапевтический архив coronary heart disease gastroduodenal pathology eradication therapy |
| title | Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| title_full | Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| title_fullStr | Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| title_full_unstemmed | Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| title_short | Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| title_sort | analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology |
| topic | coronary heart disease gastroduodenal pathology eradication therapy |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32275/pdf |
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