Graves’ Disease Caused by SARS-CoV-2 Infection
Graves’ disease is an autoimmune disorder that results in hyperthyroidism, caused by autoantibodies to the thyrotropin receptor (TRAbs) stimulating thyroid hormone synthesis, giving rise to a variety of systemic manifestations such as goitre, dermatopathy and orbitopathy. The authors present the c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2022-07-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/3470 |
| _version_ | 1798001862841991168 |
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| author | Bruno Sousa Catarina Pestana Santos Ana Gonçalves Ferreira Tiago Judas |
| author_facet | Bruno Sousa Catarina Pestana Santos Ana Gonçalves Ferreira Tiago Judas |
| author_sort | Bruno Sousa |
| collection | DOAJ |
| description | Graves’ disease is an autoimmune disorder that results in hyperthyroidism, caused by autoantibodies to the thyrotropin receptor (TRAbs) stimulating thyroid hormone synthesis, giving rise to a variety of systemic manifestations such as goitre, dermatopathy and orbitopathy.
The authors present the case of a 28-year-old man admitted to hospital for a 3-week history of fatigue, shortness of breath, palpitations and diffuse goitre, after recent mild SARS-CoV-2 infection. Laboratory investigation revealed hyperthyroidism with TRAbs elevation. Thyroid ultrasound confirmed a diffusely heterogeneous and irregular thyroid gland and a nodular image below the sternal notch. Thyroid scintigraphy excluded the nodule and confirmed a Graves’ disease pattern. Following the initiation of methimazole, the patient had complete resolution of symptoms and normalization of thyroid values.
The results suggest a possible association between Graves’ disease and SARS-CoV-2 infection acting as a trigger. Graves’ disease is an important differential diagnosis to keep in mind when patients present with hyperthyroidism after COVID-19 disease. |
| first_indexed | 2024-04-11T11:42:56Z |
| format | Article |
| id | doaj.art-0d8a2175387f4e118d0b8ee271835251 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-11T11:42:56Z |
| publishDate | 2022-07-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-0d8a2175387f4e118d0b8ee2718352512022-12-22T04:25:46ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942022-07-0110.12890/2022_0034703005Graves’ Disease Caused by SARS-CoV-2 InfectionBruno Sousa0Catarina Pestana Santos1Ana Gonçalves Ferreira2Tiago Judas3 Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, Portugal Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, PortugalEndocrinology Department, Hospital Garcia de Orta, Almada, Lisbon, Portugal Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, PortugalGraves’ disease is an autoimmune disorder that results in hyperthyroidism, caused by autoantibodies to the thyrotropin receptor (TRAbs) stimulating thyroid hormone synthesis, giving rise to a variety of systemic manifestations such as goitre, dermatopathy and orbitopathy. The authors present the case of a 28-year-old man admitted to hospital for a 3-week history of fatigue, shortness of breath, palpitations and diffuse goitre, after recent mild SARS-CoV-2 infection. Laboratory investigation revealed hyperthyroidism with TRAbs elevation. Thyroid ultrasound confirmed a diffusely heterogeneous and irregular thyroid gland and a nodular image below the sternal notch. Thyroid scintigraphy excluded the nodule and confirmed a Graves’ disease pattern. Following the initiation of methimazole, the patient had complete resolution of symptoms and normalization of thyroid values. The results suggest a possible association between Graves’ disease and SARS-CoV-2 infection acting as a trigger. Graves’ disease is an important differential diagnosis to keep in mind when patients present with hyperthyroidism after COVID-19 disease.https://www.ejcrim.com/index.php/EJCRIM/article/view/3470graves’ diseasesars-cov-2hyperthyroidism |
| spellingShingle | Bruno Sousa Catarina Pestana Santos Ana Gonçalves Ferreira Tiago Judas Graves’ Disease Caused by SARS-CoV-2 Infection European Journal of Case Reports in Internal Medicine graves’ disease sars-cov-2 hyperthyroidism |
| title | Graves’ Disease Caused by SARS-CoV-2 Infection |
| title_full | Graves’ Disease Caused by SARS-CoV-2 Infection |
| title_fullStr | Graves’ Disease Caused by SARS-CoV-2 Infection |
| title_full_unstemmed | Graves’ Disease Caused by SARS-CoV-2 Infection |
| title_short | Graves’ Disease Caused by SARS-CoV-2 Infection |
| title_sort | graves disease caused by sars cov 2 infection |
| topic | graves’ disease sars-cov-2 hyperthyroidism |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/3470 |
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