Evaluation of Borrago topical effects on wound healing of cutting wounds in mice
Introduction: Borrago Officinalis has wide effects on rheumatoid arthritis, cardiovascular disorder, gastrointestinal diseases, pulmonary disorders and skin allergies. This plant can be useful in wound healing process due to specific compounds. The aim of this study was comparative evaluation of the...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2017-07-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1849-1&slc_lang=en&sid=1 |
| _version_ | 1811341409529102336 |
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| author | Hossein kaboli Somayeh Haghighat |
| author_facet | Hossein kaboli Somayeh Haghighat |
| author_sort | Hossein kaboli |
| collection | DOAJ |
| description | Introduction: Borrago Officinalis has wide effects on rheumatoid arthritis, cardiovascular disorder, gastrointestinal diseases, pulmonary disorders and skin allergies. This plant can be useful in wound healing process due to specific compounds. The aim of this study was comparative evaluation of the effects of Borrago Officinalis with iodine and phenytoin on wound healing.
Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests.
Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups.
Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing. |
| first_indexed | 2024-04-13T18:55:08Z |
| format | Article |
| id | doaj.art-0d8ac004ae594c539e48e562ac32002b |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-04-13T18:55:08Z |
| publishDate | 2017-07-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-0d8ac004ae594c539e48e562ac32002b2022-12-22T02:34:16ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332017-07-01254311321Evaluation of Borrago topical effects on wound healing of cutting wounds in miceHossein kaboli0Somayeh Haghighat1 shahrekord univercity Isfahan univercity of medical science Introduction: Borrago Officinalis has wide effects on rheumatoid arthritis, cardiovascular disorder, gastrointestinal diseases, pulmonary disorders and skin allergies. This plant can be useful in wound healing process due to specific compounds. The aim of this study was comparative evaluation of the effects of Borrago Officinalis with iodine and phenytoin on wound healing. Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests. Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups. Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing.http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1849-1&slc_lang=en&sid=1Borrago Officinalis Wound healing Rat Iodine phenytoin |
| spellingShingle | Hossein kaboli Somayeh Haghighat Evaluation of Borrago topical effects on wound healing of cutting wounds in mice Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Borrago Officinalis Wound healing Rat Iodine phenytoin |
| title | Evaluation of Borrago topical effects on wound healing of cutting wounds in mice |
| title_full | Evaluation of Borrago topical effects on wound healing of cutting wounds in mice |
| title_fullStr | Evaluation of Borrago topical effects on wound healing of cutting wounds in mice |
| title_full_unstemmed | Evaluation of Borrago topical effects on wound healing of cutting wounds in mice |
| title_short | Evaluation of Borrago topical effects on wound healing of cutting wounds in mice |
| title_sort | evaluation of borrago topical effects on wound healing of cutting wounds in mice |
| topic | Borrago Officinalis Wound healing Rat Iodine phenytoin |
| url | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1849-1&slc_lang=en&sid=1 |
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