Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse
Coughing is common in dogs with tracheal collapse (TC). The use of inhaled corticosteroids is less widespread than oral ones. This study aims to compare the effects of oral and inhaled corticosteroids in dogs with cough and TC. Thirty dogs were prospectively included and randomized to the prednisone...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/10/9/548 |
| _version_ | 1797576367071559680 |
|---|---|
| author | Jesús Talavera-López Oscar Sáez-Mengual María-Josefa Fernández-del-Palacio |
| author_facet | Jesús Talavera-López Oscar Sáez-Mengual María-Josefa Fernández-del-Palacio |
| author_sort | Jesús Talavera-López |
| collection | DOAJ |
| description | Coughing is common in dogs with tracheal collapse (TC). The use of inhaled corticosteroids is less widespread than oral ones. This study aims to compare the effects of oral and inhaled corticosteroids in dogs with cough and TC. Thirty dogs were prospectively included and randomized to the prednisone oral group (OG, 14) or fluticasone inhaled group (IG, 16). A clinical score (CS) based on four clinical parameters (respiratory distress, cough episodes, cough frequency, tracheal sensitivity) was monitored at the hospital (enrolment and weeks 2 and 4). Water intake, urination habits, and adherence and tolerance to treatments were monitored weekly. Significant improvements in clinical parameters were identified in both groups throughout the study. Between-group (OG–IG) comparisons revealed no significant differences, indicating equivalent improvement. At the study’s endpoint, the IG dogs had a significantly lower CS (5.69 ± 0.79) than OG dogs (6.43 ± 1.02, <i>p</i> < 0.05). Adherence and tolerance were comparable. From weeks 2 to 4, OG dogs were significantly thirstier and urinated more frequently than IG dogs. In conclusion, fluticasone provided good tolerability and efficacy in controlling cough in dogs with TC, and they showed a lower incidence of signs of hypercortisolism compared to prednisone. These data encourage the use of inhaled fluticasone in dogs with cough and TC. |
| first_indexed | 2024-03-10T21:52:09Z |
| format | Article |
| id | doaj.art-0d8ae5ddf3c24bc5b3c730b291c976a7 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T21:52:09Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-0d8ae5ddf3c24bc5b3c730b291c976a72023-11-19T13:20:42ZengMDPI AGVeterinary Sciences2306-73812023-09-0110954810.3390/vetsci10090548Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal CollapseJesús Talavera-López0Oscar Sáez-Mengual1María-Josefa Fernández-del-Palacio2Cardiorespiratory Service, Veterinary Teaching Hospital of University of Murcia, Espinardo, 30100 Murcia, SpainVeterinary Clinic 7 Vidas, C/Dr Van Der Hofstan, s/n, San Juan, 03550 Alicante, SpainCardiorespiratory Service, Veterinary Teaching Hospital of University of Murcia, Espinardo, 30100 Murcia, SpainCoughing is common in dogs with tracheal collapse (TC). The use of inhaled corticosteroids is less widespread than oral ones. This study aims to compare the effects of oral and inhaled corticosteroids in dogs with cough and TC. Thirty dogs were prospectively included and randomized to the prednisone oral group (OG, 14) or fluticasone inhaled group (IG, 16). A clinical score (CS) based on four clinical parameters (respiratory distress, cough episodes, cough frequency, tracheal sensitivity) was monitored at the hospital (enrolment and weeks 2 and 4). Water intake, urination habits, and adherence and tolerance to treatments were monitored weekly. Significant improvements in clinical parameters were identified in both groups throughout the study. Between-group (OG–IG) comparisons revealed no significant differences, indicating equivalent improvement. At the study’s endpoint, the IG dogs had a significantly lower CS (5.69 ± 0.79) than OG dogs (6.43 ± 1.02, <i>p</i> < 0.05). Adherence and tolerance were comparable. From weeks 2 to 4, OG dogs were significantly thirstier and urinated more frequently than IG dogs. In conclusion, fluticasone provided good tolerability and efficacy in controlling cough in dogs with TC, and they showed a lower incidence of signs of hypercortisolism compared to prednisone. These data encourage the use of inhaled fluticasone in dogs with cough and TC.https://www.mdpi.com/2306-7381/10/9/548aerosol therapymetered-dose inhaler (MDI)airway inflammationvalved holding chamberfluticasone propionateprednisone |
| spellingShingle | Jesús Talavera-López Oscar Sáez-Mengual María-Josefa Fernández-del-Palacio Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse Veterinary Sciences aerosol therapy metered-dose inhaler (MDI) airway inflammation valved holding chamber fluticasone propionate prednisone |
| title | Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse |
| title_full | Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse |
| title_fullStr | Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse |
| title_full_unstemmed | Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse |
| title_short | Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse |
| title_sort | comparative study of inhaled fluticasone versus oral prednisone in 30 dogs with cough and tracheal collapse |
| topic | aerosol therapy metered-dose inhaler (MDI) airway inflammation valved holding chamber fluticasone propionate prednisone |
| url | https://www.mdpi.com/2306-7381/10/9/548 |
| work_keys_str_mv | AT jesustalaveralopez comparativestudyofinhaledfluticasoneversusoralprednisonein30dogswithcoughandtrachealcollapse AT oscarsaezmengual comparativestudyofinhaledfluticasoneversusoralprednisonein30dogswithcoughandtrachealcollapse AT mariajosefafernandezdelpalacio comparativestudyofinhaledfluticasoneversusoralprednisonein30dogswithcoughandtrachealcollapse |