Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study
Rationale and purpose: Although sleep disorders are shown to be involved in occurrence of diabetes, impacts of several quantitative parameters related to sleep on insulin secretion and sensitivity is yet to be elucidated. We cross-sectionally examined relationships among quantitative sleep quality,...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258993682030013X |
| _version_ | 1811222841384763392 |
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| author | Miki Kakutani-Hatayama Manabu Kadoya Akiko Morimoto Akio Miyoshi Kae Kosaka-Hamamoto Yoshiki Kusunoki Takuhito Shoji Hidenori Koyama |
| author_facet | Miki Kakutani-Hatayama Manabu Kadoya Akiko Morimoto Akio Miyoshi Kae Kosaka-Hamamoto Yoshiki Kusunoki Takuhito Shoji Hidenori Koyama |
| author_sort | Miki Kakutani-Hatayama |
| collection | DOAJ |
| description | Rationale and purpose: Although sleep disorders are shown to be involved in occurrence of diabetes, impacts of several quantitative parameters related to sleep on insulin secretion and sensitivity is yet to be elucidated. We cross-sectionally examined relationships among quantitative sleep quality, sleep apnea, and autonomic function with insulin secretion and sensitivity in 399 patients without previous diagnosed diabetes who underwent 75-g oral glucose tolerance test (75gOGTT). Method: Poor sleep quality (PSQ) was defined as an activity index ≥50 by actigraphy. Sleep apnea was measured by apnomonitor, while standard deviation of all normal-to-normal R-R intervals (SDNN) was measured by active tracer. Parameters of insulin secretion and sensitivity were measured by 75gOGTT. Results: Patients with PSQ exhibited significantly lower insulinogenic index (r = 0.155, p < 0.01), a parameter of insulin secretion, with the association independent of other clinical factors including apnea and SDNN (β = −0.156, p < 0.01). In contrast, presence of sleep apnea (r = −0.143, p < 0.05) and the lower SDNN (r = −0.150, p < 0.01) were significantly and inversely associated with BIGTT-S, an insulin sensitivity parameter, with the association of SDNN with BIGTT-S remaining significant even after adjustments for PSQ and sleep apnea (β = −0.111, p < 0.05). Conclusion: Poor sleep quality is an independent predictor of pancreatic β-cell function, which could be involved in occurrence of type 2 diabetes. |
| first_indexed | 2024-04-12T08:21:40Z |
| format | Article |
| id | doaj.art-0d8e80ff580d480db918271fa23d4fae |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-04-12T08:21:40Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-0d8e80ff580d480db918271fa23d4fae2022-12-22T03:40:32ZengElsevierMetabolism Open2589-93682020-06-016100033Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA studyMiki Kakutani-Hatayama0Manabu Kadoya1Akiko Morimoto2Akio Miyoshi3Kae Kosaka-Hamamoto4Yoshiki Kusunoki5Takuhito Shoji6Hidenori Koyama7Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanCorresponding author. Department of Internal Medicine, Division of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.; Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, JapanRationale and purpose: Although sleep disorders are shown to be involved in occurrence of diabetes, impacts of several quantitative parameters related to sleep on insulin secretion and sensitivity is yet to be elucidated. We cross-sectionally examined relationships among quantitative sleep quality, sleep apnea, and autonomic function with insulin secretion and sensitivity in 399 patients without previous diagnosed diabetes who underwent 75-g oral glucose tolerance test (75gOGTT). Method: Poor sleep quality (PSQ) was defined as an activity index ≥50 by actigraphy. Sleep apnea was measured by apnomonitor, while standard deviation of all normal-to-normal R-R intervals (SDNN) was measured by active tracer. Parameters of insulin secretion and sensitivity were measured by 75gOGTT. Results: Patients with PSQ exhibited significantly lower insulinogenic index (r = 0.155, p < 0.01), a parameter of insulin secretion, with the association independent of other clinical factors including apnea and SDNN (β = −0.156, p < 0.01). In contrast, presence of sleep apnea (r = −0.143, p < 0.05) and the lower SDNN (r = −0.150, p < 0.01) were significantly and inversely associated with BIGTT-S, an insulin sensitivity parameter, with the association of SDNN with BIGTT-S remaining significant even after adjustments for PSQ and sleep apnea (β = −0.111, p < 0.05). Conclusion: Poor sleep quality is an independent predictor of pancreatic β-cell function, which could be involved in occurrence of type 2 diabetes.http://www.sciencedirect.com/science/article/pii/S258993682030013XPancreatic β-cell functionInsulin resistanceActigraphyApnea/hypopnea indexHeart rate variabilityGlucose intolerance |
| spellingShingle | Miki Kakutani-Hatayama Manabu Kadoya Akiko Morimoto Akio Miyoshi Kae Kosaka-Hamamoto Yoshiki Kusunoki Takuhito Shoji Hidenori Koyama Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study Metabolism Open Pancreatic β-cell function Insulin resistance Actigraphy Apnea/hypopnea index Heart rate variability Glucose intolerance |
| title | Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study |
| title_full | Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study |
| title_fullStr | Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study |
| title_full_unstemmed | Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study |
| title_short | Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study |
| title_sort | associations of sleep quality sleep apnea and autonomic function with insulin secretion and sensitivity hscaa study |
| topic | Pancreatic β-cell function Insulin resistance Actigraphy Apnea/hypopnea index Heart rate variability Glucose intolerance |
| url | http://www.sciencedirect.com/science/article/pii/S258993682030013X |
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