Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors
Endogenous cannabinoid system plays an important physiologicalrole in brain functioning, being related to regulation of neuromediatorprocesses and mechanisms of neuroplasticity.Cannabinoid receptors of type 1 (CB1) represent one of the keyelements of this system and convenient object for various exp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2007-06-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/437/333 |
| _version_ | 1811337870075494400 |
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| author | L. E. Frumkina M. Yu. Bobrov A. A. Lyzhin E. L. Andrianova S. K. Koroleva N. A. Bobrova L. G. Khaspekov |
| author_facet | L. E. Frumkina M. Yu. Bobrov A. A. Lyzhin E. L. Andrianova S. K. Koroleva N. A. Bobrova L. G. Khaspekov |
| author_sort | L. E. Frumkina |
| collection | DOAJ |
| description | Endogenous cannabinoid system plays an important physiologicalrole in brain functioning, being related to regulation of neuromediatorprocesses and mechanisms of neuroplasticity.Cannabinoid receptors of type 1 (CB1) represent one of the keyelements of this system and convenient object for various experimentaleffects. We showed plastic reorganization of synapses inhippocampal CA1 stratum radiatum in vitro resulted from pharmacologicalblockade of CB1. The ultrastructural features of thisreorganization are the formation of numerous perforated contactswith elongated synaptic membranes of modified configuration,spatial synaptic rearrangement, and the appearance ofatypical synaptic connections. The obtained results suggest thatinvolvement of CB1 in modulation of synaptic transmission isone of the mechanisms which ensure the stable morphofunctionalstate of synapse and promote its integrity in disturbancesof neurotransmission regulation. |
| first_indexed | 2024-04-13T18:02:15Z |
| format | Article |
| id | doaj.art-0d8f799af4f04fd88d148d379f06b262 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-13T18:02:15Z |
| publishDate | 2007-06-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-0d8f799af4f04fd88d148d379f06b2622022-12-22T02:36:12ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332007-06-0112172110.17816/psaic437332Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptorsL. E. Frumkina0M. Yu. Bobrov1A. A. Lyzhin2E. L. Andrianova3S. K. Koroleva4N. A. Bobrova5L. G. Khaspekov6Research Center of NeurologyShemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Medical Sciences, MoscowResearch Center of NeurologyShemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Medical Sciences, MoscowResearch Center of NeurologyRussian State Medical University, MoscowResearch Center of NeurologyEndogenous cannabinoid system plays an important physiologicalrole in brain functioning, being related to regulation of neuromediatorprocesses and mechanisms of neuroplasticity.Cannabinoid receptors of type 1 (CB1) represent one of the keyelements of this system and convenient object for various experimentaleffects. We showed plastic reorganization of synapses inhippocampal CA1 stratum radiatum in vitro resulted from pharmacologicalblockade of CB1. The ultrastructural features of thisreorganization are the formation of numerous perforated contactswith elongated synaptic membranes of modified configuration,spatial synaptic rearrangement, and the appearance ofatypical synaptic connections. The obtained results suggest thatinvolvement of CB1 in modulation of synaptic transmission isone of the mechanisms which ensure the stable morphofunctionalstate of synapse and promote its integrity in disturbancesof neurotransmission regulation.https://annaly-nevrologii.com/journal/pathID/article/viewFile/437/333hippocampustissue culturecannabinoid receptorssynaptic regulationplasticityglutamateneurotoxicity |
| spellingShingle | L. E. Frumkina M. Yu. Bobrov A. A. Lyzhin E. L. Andrianova S. K. Koroleva N. A. Bobrova L. G. Khaspekov Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors Анналы клинической и экспериментальной неврологии hippocampus tissue culture cannabinoid receptors synaptic regulation plasticity glutamate neurotoxicity |
| title | Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| title_full | Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| title_fullStr | Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| title_full_unstemmed | Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| title_short | Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| title_sort | plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors |
| topic | hippocampus tissue culture cannabinoid receptors synaptic regulation plasticity glutamate neurotoxicity |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/437/333 |
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