MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers
Infertility affects approximately 10–15% of couples worldwide who are attempting to conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related to various factors such as hormone imbalance, urogenital diseases, environmental factors, and genetic factors. Owin...
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| 格式: | 文件 |
| 语言: | English |
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Frontiers Media S.A.
2024-02-01
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| 丛编: | Frontiers in Endocrinology |
| 主题: | |
| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1293368/full |
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| author | Ziyan Shi Ziyan Shi Miao Yu Tingchao Guo Yu Sui Zhiying Tian Xiang Ni Xinren Chen Miao Jiang Jingyi Jiang Yongping Lu Meina Lin |
| author_facet | Ziyan Shi Ziyan Shi Miao Yu Tingchao Guo Yu Sui Zhiying Tian Xiang Ni Xinren Chen Miao Jiang Jingyi Jiang Yongping Lu Meina Lin |
| author_sort | Ziyan Shi |
| collection | DOAJ |
| description | Infertility affects approximately 10–15% of couples worldwide who are attempting to conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related to various factors such as hormone imbalance, urogenital diseases, environmental factors, and genetic factors. Owing to its relationship with genetic factors, male infertility cannot be diagnosed through routine examination in most cases, and is clinically called ‘idiopathic male infertility.’ Recent studies have provided evidence that microRNAs (miRNAs) are expressed in a cell-or stage-specific manner during spermatogenesis. This review focuses on the role of miRNAs in male infertility and spermatogenesis. Data were collected from published studies that investigated the effects of miRNAs on spermatogenesis, sperm quality and quantity, fertilization, embryo development, and assisted reproductive technology (ART) outcomes. Based on the findings of these studies, we summarize the targets of miRNAs and the resulting functional effects that occur due to changes in miRNA expression at various stages of spermatogenesis, including undifferentiated and differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells (SCs). In addition, we discuss potential markers for diagnosing male infertility and predicting the varicocele grade, surgical outcomes, ART outcomes, and sperm retrieval rates in patients with non-obstructive azoospermia (NOA). |
| first_indexed | 2024-03-07T23:14:40Z |
| format | Article |
| id | doaj.art-0d9025741b5d4481a5fd6a5f69fdfae3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:14:40Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0d9025741b5d4481a5fd6a5f69fdfae32024-02-21T13:01:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.12933681293368MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkersZiyan Shi0Ziyan Shi1Miao Yu2Tingchao Guo3Yu Sui4Zhiying Tian5Xiang Ni6Xinren Chen7Miao Jiang8Jingyi Jiang9Yongping Lu10Meina Lin11NHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaDepartment of Biochemistry & Molecular Biology, China Medical University, Shenyang, ChinaScience Experiment Center, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaDepartment of Biochemistry & Molecular Biology, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, China Medical University, Shenyang, ChinaInfertility affects approximately 10–15% of couples worldwide who are attempting to conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related to various factors such as hormone imbalance, urogenital diseases, environmental factors, and genetic factors. Owing to its relationship with genetic factors, male infertility cannot be diagnosed through routine examination in most cases, and is clinically called ‘idiopathic male infertility.’ Recent studies have provided evidence that microRNAs (miRNAs) are expressed in a cell-or stage-specific manner during spermatogenesis. This review focuses on the role of miRNAs in male infertility and spermatogenesis. Data were collected from published studies that investigated the effects of miRNAs on spermatogenesis, sperm quality and quantity, fertilization, embryo development, and assisted reproductive technology (ART) outcomes. Based on the findings of these studies, we summarize the targets of miRNAs and the resulting functional effects that occur due to changes in miRNA expression at various stages of spermatogenesis, including undifferentiated and differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells (SCs). In addition, we discuss potential markers for diagnosing male infertility and predicting the varicocele grade, surgical outcomes, ART outcomes, and sperm retrieval rates in patients with non-obstructive azoospermia (NOA).https://www.frontiersin.org/articles/10.3389/fendo.2024.1293368/fullmale infertilityspermMicroRNAsNOAdiagnostic markers |
| spellingShingle | Ziyan Shi Ziyan Shi Miao Yu Tingchao Guo Yu Sui Zhiying Tian Xiang Ni Xinren Chen Miao Jiang Jingyi Jiang Yongping Lu Meina Lin MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers Frontiers in Endocrinology male infertility sperm MicroRNAs NOA diagnostic markers |
| title | MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers |
| title_full | MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers |
| title_fullStr | MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers |
| title_full_unstemmed | MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers |
| title_short | MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers |
| title_sort | micrornas in spermatogenesis dysfunction and male infertility clinical phenotypes mechanisms and potential diagnostic biomarkers |
| topic | male infertility sperm MicroRNAs NOA diagnostic markers |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1293368/full |
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