Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
To investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and...
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MDPI AG
2021-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/11/1467 |
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| author | Xiaoyin Wu Fang Lin Weiting Sun Tingzhen Zhang Huiwen Sun Jun Li |
| author_facet | Xiaoyin Wu Fang Lin Weiting Sun Tingzhen Zhang Huiwen Sun Jun Li |
| author_sort | Xiaoyin Wu |
| collection | DOAJ |
| description | To investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and 22 age-matched TD children. The resting state fNIRS signals, including spontaneous fluctuations in the oxygenated hemoglobin (HbO<sub>2</sub>) and deoxygenated hemoglobin (Hb) concentrations, were recorded from the bilateral temporal lobes. We found that (1) there was no difference in the short-range RSFC between the left and right hemisphere in either ASD or TD group; (2) both the short-range and homotopic long-range RSFC were weaker in the ASD than TD group; and (3) the short-range RSFC was stronger than the homotopic long-range RSFC in the ASD group, whereas no such difference was observed in the TD group. These observations might be helpful for a better understanding of the underlying cortical mechanism in ASD. |
| first_indexed | 2024-03-10T05:38:57Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T05:38:57Z |
| publishDate | 2021-11-01 |
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| series | Brain Sciences |
| spelling | doaj.art-0d90fe8cebc04783997b94ab69ad386f2023-11-22T22:38:07ZengMDPI AGBrain Sciences2076-34252021-11-011111146710.3390/brainsci11111467Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum DisorderXiaoyin Wu0Fang Lin1Weiting Sun2Tingzhen Zhang3Huiwen Sun4Jun Li5South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaSouth China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaSouth China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaSouth China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaSouth China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaSouth China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, ChinaTo investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and 22 age-matched TD children. The resting state fNIRS signals, including spontaneous fluctuations in the oxygenated hemoglobin (HbO<sub>2</sub>) and deoxygenated hemoglobin (Hb) concentrations, were recorded from the bilateral temporal lobes. We found that (1) there was no difference in the short-range RSFC between the left and right hemisphere in either ASD or TD group; (2) both the short-range and homotopic long-range RSFC were weaker in the ASD than TD group; and (3) the short-range RSFC was stronger than the homotopic long-range RSFC in the ASD group, whereas no such difference was observed in the TD group. These observations might be helpful for a better understanding of the underlying cortical mechanism in ASD.https://www.mdpi.com/2076-3425/11/11/1467autism spectrum disorder (ASD)functional near-infrared spectroscopy (fNIRS)resting-state functional connectivity (RSFC)short-range RSFClong-range RSFC |
| spellingShingle | Xiaoyin Wu Fang Lin Weiting Sun Tingzhen Zhang Huiwen Sun Jun Li Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder Brain Sciences autism spectrum disorder (ASD) functional near-infrared spectroscopy (fNIRS) resting-state functional connectivity (RSFC) short-range RSFC long-range RSFC |
| title | Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder |
| title_full | Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder |
| title_fullStr | Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder |
| title_full_unstemmed | Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder |
| title_short | Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder |
| title_sort | relationship between short range and homotopic long range resting state functional connectivity in temporal lobes in autism spectrum disorder |
| topic | autism spectrum disorder (ASD) functional near-infrared spectroscopy (fNIRS) resting-state functional connectivity (RSFC) short-range RSFC long-range RSFC |
| url | https://www.mdpi.com/2076-3425/11/11/1467 |
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