Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms
Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic function, clearance of cellular debris, and t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.620510/full |
| _version_ | 1818558741912485888 |
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| author | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson Aaron C. Ericsson |
| author_facet | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson Aaron C. Ericsson |
| author_sort | Chunye Zhang |
| collection | DOAJ |
| description | Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic function, clearance of cellular debris, and tissue remodeling and defense. Macrophages can be polarized to different functional phenotypes depending on their origin and tissue microenvironment. Specific macrophage subpopulations are associated with disease progression. In studies of fate-mapping and single-cell RNA sequencing methodologies, several critical molecules have been identified to induce the change of macrophage function. These molecules are potential markers for diagnosis and selective targets for novel macrophage-mediated treatment. In this review, we discuss some of the recent findings regarding less-known molecules and new functions of well-known molecules. Understanding the mechanisms of these molecules in macrophages has the potential to yield new macrophage-mediated treatments or diagnostic approaches to disease. |
| first_indexed | 2024-12-14T00:16:17Z |
| format | Article |
| id | doaj.art-0d91bd1ce75446658fdb285e23339a89 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T00:16:17Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0d91bd1ce75446658fdb285e23339a892022-12-21T23:25:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.620510620510Function of Macrophages in Disease: Current Understanding on Molecular MechanismsChunye Zhang0Ming Yang1Aaron C. Ericsson2Aaron C. Ericsson3Aaron C. Ericsson4Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United StatesDepartment of Surgery, University of Missouri, Columbia, MO, United StatesDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO, United StatesDepartment of Veterinary Pathobiology, University of Missouri Metagenomics Center, University of Missouri, Columbia, MO, United StatesDepartment of Veterinary Pathobiology, University of Missouri Mutant Mouse Resource and Research Center, Columbia, MO, United StatesTissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic function, clearance of cellular debris, and tissue remodeling and defense. Macrophages can be polarized to different functional phenotypes depending on their origin and tissue microenvironment. Specific macrophage subpopulations are associated with disease progression. In studies of fate-mapping and single-cell RNA sequencing methodologies, several critical molecules have been identified to induce the change of macrophage function. These molecules are potential markers for diagnosis and selective targets for novel macrophage-mediated treatment. In this review, we discuss some of the recent findings regarding less-known molecules and new functions of well-known molecules. Understanding the mechanisms of these molecules in macrophages has the potential to yield new macrophage-mediated treatments or diagnostic approaches to disease.https://www.frontiersin.org/articles/10.3389/fimmu.2021.620510/fullmacrophagephenotypemoleculesdiagnostic markertherapy |
| spellingShingle | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson Aaron C. Ericsson Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms Frontiers in Immunology macrophage phenotype molecules diagnostic marker therapy |
| title | Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms |
| title_full | Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms |
| title_fullStr | Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms |
| title_full_unstemmed | Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms |
| title_short | Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms |
| title_sort | function of macrophages in disease current understanding on molecular mechanisms |
| topic | macrophage phenotype molecules diagnostic marker therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.620510/full |
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