Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation
Breakthroughs in the biomedical and regenerative therapy fields have led to the influential ability of stem cells to differentiate into specific types of cells that enable the replacement of injured tissues/organs in the human body. Non-destructive identification of stem cell differentiation is high...
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MDPI AG
2018-08-01
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Online Access: | http://www.mdpi.com/1424-8220/18/9/2755 |
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author | Intan Rosalina Suhito Novi Angeline Sung-Sik Choo Ho Young Woo Taejong Paik Taek Lee Tae-Hyung Kim |
author_facet | Intan Rosalina Suhito Novi Angeline Sung-Sik Choo Ho Young Woo Taejong Paik Taek Lee Tae-Hyung Kim |
author_sort | Intan Rosalina Suhito |
collection | DOAJ |
description | Breakthroughs in the biomedical and regenerative therapy fields have led to the influential ability of stem cells to differentiate into specific types of cells that enable the replacement of injured tissues/organs in the human body. Non-destructive identification of stem cell differentiation is highly necessary to avoid losses of differentiated cells, because most of the techniques generally used as confirmation tools for the successful differentiation of stem cells can result in valuable cells becoming irrecoverable. Regarding this issue, recent studies reported that both Raman spectroscopy and electrochemical sensing possess excellent characteristics for monitoring the behavior of stem cells, including differentiation. In this review, we focus on numerous studies that have investigated the detection of stem cell pluripotency and differentiation in non-invasive and non-destructive manner, mainly by using the Raman and electrochemical methods. Through this review, we present information that could provide scientific or technical motivation to employ or further develop these two techniques for stem cell research and its application. |
first_indexed | 2024-04-11T22:19:47Z |
format | Article |
id | doaj.art-0d92cc4205a44784b2806f418a3db0c9 |
institution | Directory Open Access Journal |
issn | 1424-8220 |
language | English |
last_indexed | 2024-04-11T22:19:47Z |
publishDate | 2018-08-01 |
publisher | MDPI AG |
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series | Sensors |
spelling | doaj.art-0d92cc4205a44784b2806f418a3db0c92022-12-22T04:00:14ZengMDPI AGSensors1424-82202018-08-01189275510.3390/s18092755s18092755Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and DifferentiationIntan Rosalina Suhito0Novi Angeline1Sung-Sik Choo2Ho Young Woo3Taejong Paik4Taek Lee5Tae-Hyung Kim6School of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul 0189, KoreaSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaBreakthroughs in the biomedical and regenerative therapy fields have led to the influential ability of stem cells to differentiate into specific types of cells that enable the replacement of injured tissues/organs in the human body. Non-destructive identification of stem cell differentiation is highly necessary to avoid losses of differentiated cells, because most of the techniques generally used as confirmation tools for the successful differentiation of stem cells can result in valuable cells becoming irrecoverable. Regarding this issue, recent studies reported that both Raman spectroscopy and electrochemical sensing possess excellent characteristics for monitoring the behavior of stem cells, including differentiation. In this review, we focus on numerous studies that have investigated the detection of stem cell pluripotency and differentiation in non-invasive and non-destructive manner, mainly by using the Raman and electrochemical methods. Through this review, we present information that could provide scientific or technical motivation to employ or further develop these two techniques for stem cell research and its application.http://www.mdpi.com/1424-8220/18/9/2755stem cellsdifferentiationpluripotencyelectrochemical detectionRaman spectroscopy |
spellingShingle | Intan Rosalina Suhito Novi Angeline Sung-Sik Choo Ho Young Woo Taejong Paik Taek Lee Tae-Hyung Kim Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation Sensors stem cells differentiation pluripotency electrochemical detection Raman spectroscopy |
title | Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation |
title_full | Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation |
title_fullStr | Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation |
title_full_unstemmed | Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation |
title_short | Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation |
title_sort | nanobiosensing platforms for real time and non invasive monitoring of stem cell pluripotency and differentiation |
topic | stem cells differentiation pluripotency electrochemical detection Raman spectroscopy |
url | http://www.mdpi.com/1424-8220/18/9/2755 |
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