Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-02-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087614000555 |
| _version_ | 1818216801055539200 |
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| author | Varaporn Buraphacheep Junyaprasert Boontida Morakul |
| author_facet | Varaporn Buraphacheep Junyaprasert Boontida Morakul |
| author_sort | Varaporn Buraphacheep Junyaprasert |
| collection | DOAJ |
| description | Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied for nanocrystals production including precipitation, milling, high pressure homogenization and combination methods such as NanoEdge™, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology. For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which were discussed in this review. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals were also described. |
| first_indexed | 2024-12-12T06:57:44Z |
| format | Article |
| id | doaj.art-0d946bea10604707840ba01b8d506ddd |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-12T06:57:44Z |
| publishDate | 2015-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-0d946bea10604707840ba01b8d506ddd2022-12-22T00:33:54ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-02-01101132310.1016/j.ajps.2014.08.005Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugsVaraporn Buraphacheep Junyaprasert0Boontida Morakul1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, ThailandDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, ThailandNanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied for nanocrystals production including precipitation, milling, high pressure homogenization and combination methods such as NanoEdge™, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology. For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which were discussed in this review. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals were also described.http://www.sciencedirect.com/science/article/pii/S1818087614000555NanocrystalsBioavailabilityPoorly water-soluble drugs |
| spellingShingle | Varaporn Buraphacheep Junyaprasert Boontida Morakul Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs Asian Journal of Pharmaceutical Sciences Nanocrystals Bioavailability Poorly water-soluble drugs |
| title | Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs |
| title_full | Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs |
| title_fullStr | Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs |
| title_full_unstemmed | Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs |
| title_short | Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs |
| title_sort | nanocrystals for enhancement of oral bioavailability of poorly water soluble drugs |
| topic | Nanocrystals Bioavailability Poorly water-soluble drugs |
| url | http://www.sciencedirect.com/science/article/pii/S1818087614000555 |
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