TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/878 |
| _version_ | 1826853624925388800 |
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| author | A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov |
| author_facet | A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov |
| author_sort | A. A. Alshevskaya |
| collection | DOAJ |
| description | TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content of soluble receptors and expression of membrane-bound receptors. The study shows several significant differences not only in the percentage of cells with. TNFα receptors, but also in the absolute number of receptors expressed on cells from different subsets of immunocompetent cells in health and in rheumatoid arthritis, establishes correlation relationships of these parameters with serum contents of the cytokine and its soluble receptors. The mechanisms and the role of changes in the expression of TNFα receptors in different subsets of leukocytes in immunopathological state and in compare with healthy donors are discussed. |
| first_indexed | 2024-03-08T12:22:46Z |
| format | Article |
| id | doaj.art-0d9495723b1d4de8a34f6e6fa6e0a7e8 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:30:06Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-0d9495723b1d4de8a34f6e6fa6e0a7e82025-01-27T16:48:36ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)2328824TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITISA. A. Alshevskaya0F. F. Vasiliev1J. A. Lopatnikova2S. V. Sennikov3Research Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSTNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content of soluble receptors and expression of membrane-bound receptors. The study shows several significant differences not only in the percentage of cells with. TNFα receptors, but also in the absolute number of receptors expressed on cells from different subsets of immunocompetent cells in health and in rheumatoid arthritis, establishes correlation relationships of these parameters with serum contents of the cytokine and its soluble receptors. The mechanisms and the role of changes in the expression of TNFα receptors in different subsets of leukocytes in immunopathological state and in compare with healthy donors are discussed.https://www.actabiomedica.ru/jour/article/view/878tnfαtnfαmembrane-bound receptorsrheumatoid arthritis |
| spellingShingle | A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS Acta Biomedica Scientifica tnfα tnfα membrane-bound receptors rheumatoid arthritis |
| title | TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS |
| title_full | TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS |
| title_fullStr | TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS |
| title_full_unstemmed | TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS |
| title_short | TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS |
| title_sort | tumor necrosis factor α membrane bound and soluble receptors in norm and in rheumatoid arthritis |
| topic | tnfα tnfα membrane-bound receptors rheumatoid arthritis |
| url | https://www.actabiomedica.ru/jour/article/view/878 |
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