Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial
BackgroundMost external peripheral nerve stimulation devices designed to alter mood states use electrical energy, but mechanical stimulation for activation of somatosensory pathways may be harnessed for potential therapeutic neuromodulation. A novel investigational device for Mechanical Affective To...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877574/full |
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| author | Linda L. Carpenter Linda L. Carpenter Eugenia F. Kronenberg Eric Tirrell Fatih Kokdere Fatih Kokdere Quincy M. Beck Simona Temereanca Andrew M. Fukuda Andrew M. Fukuda Sahithi Garikapati Sean Hagberg |
| author_facet | Linda L. Carpenter Linda L. Carpenter Eugenia F. Kronenberg Eric Tirrell Fatih Kokdere Fatih Kokdere Quincy M. Beck Simona Temereanca Andrew M. Fukuda Andrew M. Fukuda Sahithi Garikapati Sean Hagberg |
| author_sort | Linda L. Carpenter |
| collection | DOAJ |
| description | BackgroundMost external peripheral nerve stimulation devices designed to alter mood states use electrical energy, but mechanical stimulation for activation of somatosensory pathways may be harnessed for potential therapeutic neuromodulation. A novel investigational device for Mechanical Affective Touch Therapy (MATT) was created to stimulate C-tactile fibers through gentle vibrations delivered by piezoelectric actuators on the bilateral mastoid processes.Methods22 adults with anxiety disorders and at least moderate anxiety symptom severity enrolled in an open-label pilot trial that involved MATT self-administration using a simple headset at home at least twice per day for 4 weeks. Resting EEG data were acquired before and after a baseline MATT session and again before the final MATT session. Self-report measures of mood and anxiety were collected at baseline, week 2, and week 4, while interoception was assessed pre- and post-treatment.ResultsAnxiety and depressive symptoms improved significantly from baseline to endpoint, and mindfulness was enhanced. EEG metrics confirmed an association between acute MATT stimulation and oscillatory power in alpha and theta bands; symptom changes correlated with changes in some metrics.ConclusionOpen-label data suggest MATT is a promising non-invasive therapeutic approach to anxiety disorders that warrants further development. |
| first_indexed | 2024-04-11T21:13:34Z |
| format | Article |
| id | doaj.art-0d94d4bc63274044af592ade586b2860 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T21:13:34Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-0d94d4bc63274044af592ade586b28602022-12-22T04:02:53ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.877574877574Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label TrialLinda L. Carpenter0Linda L. Carpenter1Eugenia F. Kronenberg2Eric Tirrell3Fatih Kokdere4Fatih Kokdere5Quincy M. Beck6Simona Temereanca7Andrew M. Fukuda8Andrew M. Fukuda9Sahithi Garikapati10Sean Hagberg11Neuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Neuroscience, Brown University, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United StatesAffect Neuro Inc., Brooklyn, NY, United StatesAffect Neuro Inc., Brooklyn, NY, United StatesBackgroundMost external peripheral nerve stimulation devices designed to alter mood states use electrical energy, but mechanical stimulation for activation of somatosensory pathways may be harnessed for potential therapeutic neuromodulation. A novel investigational device for Mechanical Affective Touch Therapy (MATT) was created to stimulate C-tactile fibers through gentle vibrations delivered by piezoelectric actuators on the bilateral mastoid processes.Methods22 adults with anxiety disorders and at least moderate anxiety symptom severity enrolled in an open-label pilot trial that involved MATT self-administration using a simple headset at home at least twice per day for 4 weeks. Resting EEG data were acquired before and after a baseline MATT session and again before the final MATT session. Self-report measures of mood and anxiety were collected at baseline, week 2, and week 4, while interoception was assessed pre- and post-treatment.ResultsAnxiety and depressive symptoms improved significantly from baseline to endpoint, and mindfulness was enhanced. EEG metrics confirmed an association between acute MATT stimulation and oscillatory power in alpha and theta bands; symptom changes correlated with changes in some metrics.ConclusionOpen-label data suggest MATT is a promising non-invasive therapeutic approach to anxiety disorders that warrants further development.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877574/fullperipheral nerve stimulationacoustic stimulationtherapeutic neuromodulationanxietyEEG |
| spellingShingle | Linda L. Carpenter Linda L. Carpenter Eugenia F. Kronenberg Eric Tirrell Fatih Kokdere Fatih Kokdere Quincy M. Beck Simona Temereanca Andrew M. Fukuda Andrew M. Fukuda Sahithi Garikapati Sean Hagberg Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial Frontiers in Psychiatry peripheral nerve stimulation acoustic stimulation therapeutic neuromodulation anxiety EEG |
| title | Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial |
| title_full | Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial |
| title_fullStr | Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial |
| title_full_unstemmed | Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial |
| title_short | Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial |
| title_sort | mechanical affective touch therapy for anxiety disorders feasibility clinical outcomes and electroencephalography biomarkers from an open label trial |
| topic | peripheral nerve stimulation acoustic stimulation therapeutic neuromodulation anxiety EEG |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877574/full |
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