2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties

Among the most recent proposals regarding the mechanism of action of dipyrone, the modulation of cannabinoid receptors CB<sub>1</sub> and CB<sub>2</sub> appears to be a promising hypothesis. In this context, the present work describes a series of five novel pyrazolamides (<...

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Bibliographic Details
Main Authors: Daniela R. de Oliveira, Rodolfo C. Maia, Patrícia R. de Carvalho França, Patrícia D. Fernandes, Gisele Barbosa, Lídia M. Lima, Carlos A. Manssour Fraga
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
dipyrone
metamizole
cannabinoid receptors
CB<sub>2</sub> inverse agonists
pyrazolamides
molecular hybridization
Online Access:https://www.mdpi.com/1424-8247/15/12/1519

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