Construction of cardiac fibrosis for biomedical research
Abstract Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-08-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20230020 |
| _version_ | 1797733452755238912 |
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| author | Yixuan Shang Rui Liu Jingjing Gan Yuzhi Yang Lingyun Sun |
| author_facet | Yixuan Shang Rui Liu Jingjing Gan Yuzhi Yang Lingyun Sun |
| author_sort | Yixuan Shang |
| collection | DOAJ |
| description | Abstract Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for this issue. Understanding the detrimental cardiac remodeling may aid in the development of innovative treatment strategies to prevent or reverse fibrotic alterations in the heart. Further combining the latest understanding of disease pathogenesis with cardiac tissue engineering has provided the conversion of basic laboratory studies into the therapy of cardiac fibrosis patients as an increasingly viable prospect. This review presents the current main mechanisms and the potential tissue engineering of cardiac fibrosis. Approaches using biomedical materials‐based cardiac constructions are reviewed to consider key issues for simulating in vitro cardiac fibrosis, outlining a future perspective for preclinical applications. |
| first_indexed | 2024-03-12T12:28:22Z |
| format | Article |
| id | doaj.art-0d96f946950f420eaafb41ae21e24712 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-12T12:28:22Z |
| publishDate | 2023-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-0d96f946950f420eaafb41ae21e247122023-08-29T17:51:25ZengWiley-VCHSmart Medicine2751-18712023-08-0123n/an/a10.1002/SMMD.20230020Construction of cardiac fibrosis for biomedical researchYixuan Shang0Rui Liu1Jingjing Gan2Yuzhi Yang3Lingyun Sun4Department of Medical Supplies Support Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDepartment of Medical Supplies Support Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaAbstract Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for this issue. Understanding the detrimental cardiac remodeling may aid in the development of innovative treatment strategies to prevent or reverse fibrotic alterations in the heart. Further combining the latest understanding of disease pathogenesis with cardiac tissue engineering has provided the conversion of basic laboratory studies into the therapy of cardiac fibrosis patients as an increasingly viable prospect. This review presents the current main mechanisms and the potential tissue engineering of cardiac fibrosis. Approaches using biomedical materials‐based cardiac constructions are reviewed to consider key issues for simulating in vitro cardiac fibrosis, outlining a future perspective for preclinical applications.https://doi.org/10.1002/SMMD.20230020biomedical materialscardiac fibrosisdrug screeningtissue engineer |
| spellingShingle | Yixuan Shang Rui Liu Jingjing Gan Yuzhi Yang Lingyun Sun Construction of cardiac fibrosis for biomedical research Smart Medicine biomedical materials cardiac fibrosis drug screening tissue engineer |
| title | Construction of cardiac fibrosis for biomedical research |
| title_full | Construction of cardiac fibrosis for biomedical research |
| title_fullStr | Construction of cardiac fibrosis for biomedical research |
| title_full_unstemmed | Construction of cardiac fibrosis for biomedical research |
| title_short | Construction of cardiac fibrosis for biomedical research |
| title_sort | construction of cardiac fibrosis for biomedical research |
| topic | biomedical materials cardiac fibrosis drug screening tissue engineer |
| url | https://doi.org/10.1002/SMMD.20230020 |
| work_keys_str_mv | AT yixuanshang constructionofcardiacfibrosisforbiomedicalresearch AT ruiliu constructionofcardiacfibrosisforbiomedicalresearch AT jingjinggan constructionofcardiacfibrosisforbiomedicalresearch AT yuzhiyang constructionofcardiacfibrosisforbiomedicalresearch AT lingyunsun constructionofcardiacfibrosisforbiomedicalresearch |