Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination
MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00369/full |
| _version_ | 1818115394551939072 |
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| author | Kyung Jin eCho Paul A. Roche |
| author_facet | Kyung Jin eCho Paul A. Roche |
| author_sort | Kyung Jin eCho |
| collection | DOAJ |
| description | MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently been shown to be a key regulator of MHC-II expression in dendritic cells (DCs). In this mini-review we will examine the mechanism by which the E3 ubiquitin ligase March-I regulates MHC-II expression on APCs and will discuss the functional consequences of altering MHC-II ubiquitination. |
| first_indexed | 2024-12-11T04:05:56Z |
| format | Article |
| id | doaj.art-0d9908bf0816454c96e2a072ba90f66c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T04:05:56Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0d9908bf0816454c96e2a072ba90f66c2022-12-22T01:21:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0036964295Regulation of MHC Class II-Peptide Complex Expression by UbiquitinationKyung Jin eCho0Paul A. Roche1National Institutes of HealthNational Institutes of HealthMHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently been shown to be a key regulator of MHC-II expression in dendritic cells (DCs). In this mini-review we will examine the mechanism by which the E3 ubiquitin ligase March-I regulates MHC-II expression on APCs and will discuss the functional consequences of altering MHC-II ubiquitination.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00369/fullEndocytosisRecyclingUbiquitinationdegradationMHC class IIMarch-I |
| spellingShingle | Kyung Jin eCho Paul A. Roche Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination Frontiers in Immunology Endocytosis Recycling Ubiquitination degradation MHC class II March-I |
| title | Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination |
| title_full | Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination |
| title_fullStr | Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination |
| title_full_unstemmed | Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination |
| title_short | Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination |
| title_sort | regulation of mhc class ii peptide complex expression by ubiquitination |
| topic | Endocytosis Recycling Ubiquitination degradation MHC class II March-I |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00369/full |
| work_keys_str_mv | AT kyungjinecho regulationofmhcclassiipeptidecomplexexpressionbyubiquitination AT paularoche regulationofmhcclassiipeptidecomplexexpressionbyubiquitination |