Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Abstract Background Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is difficult to generate large amounts of ELCs with high quality because they...

Full description

Bibliographic Details
Main Authors: Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Stem Cell Research & Therapy
Subjects:
Intestinal organoids
Small intestine
iPS cell
Drug-metabolizing enzymes
Drug transporters
Online Access:https://doi.org/10.1186/s13287-024-03685-5

Internet

https://doi.org/10.1186/s13287-024-03685-5

Similar Items