Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research
Abstract Background Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is difficult to generate large amounts of ELCs with high quality because they...
Main Authors: | Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2024-02-01
|
Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13287-024-03685-5 |
Similar Items
-
Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation
by: Tomohiro Shintani, et al.
Published: (2023-09-01) -
Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine
by: Nina Kramer, et al.
Published: (2020-03-01) -
Porcine Intestinal Organoids: Overview of the State of the Art
by: Panpan Ma, et al.
Published: (2022-05-01) -
Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes
by: Agnese Filippello, et al.
Published: (2022-07-01) -
Application Research Progress of Intestinal Organoids in Nutrient Absorption
by: Yaxuan PENG, et al.
Published: (2022-12-01)