Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys
Ochratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey. Donkeys received a single orally dose of 2500 μg OTA/kg BW, obtained from <i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/2/88 |
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| author | Ruifen Kang Honglei Qu Yanxin Guo Mengjie Zhang Tianze Fu Shimeng Huang Lihong Zhao Jianyun Zhang Cheng Ji Qiugang Ma |
| author_facet | Ruifen Kang Honglei Qu Yanxin Guo Mengjie Zhang Tianze Fu Shimeng Huang Lihong Zhao Jianyun Zhang Cheng Ji Qiugang Ma |
| author_sort | Ruifen Kang |
| collection | DOAJ |
| description | Ochratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey. Donkeys received a single orally dose of 2500 μg OTA/kg BW, obtained from <i>Aspergillus ochraceus</i> culture material. The concentrations of OTA in plasma collected at 0, 5, 10, 15, 20, 30, 45 min, and at 1, 1.5, 2, 3, 6, 9, 12, 24, 48, 72, 96 and 120 h were detected by HPLC. OTA eliminated in urine and feces were quantified at 6-h intervals up to 24 h and then at 4-h intervals up to 120 h. The results suggested that the maximum concentration of OTA in plasma was observed at 12 h after administration, with a mean value of 10.34 μg/mL. The total excretion in both urine and feces was about 10% of the intake until 120 h. |
| first_indexed | 2024-03-11T08:03:29Z |
| format | Article |
| id | doaj.art-0da19b112bcf4f288eedb828fd39778c |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-11T08:03:29Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-0da19b112bcf4f288eedb828fd39778c2023-11-16T23:38:24ZengMDPI AGToxins2072-66512023-01-011528810.3390/toxins15020088Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male DonkeysRuifen Kang0Honglei Qu1Yanxin Guo2Mengjie Zhang3Tianze Fu4Shimeng Huang5Lihong Zhao6Jianyun Zhang7Cheng Ji8Qiugang Ma9State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaOchratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey. Donkeys received a single orally dose of 2500 μg OTA/kg BW, obtained from <i>Aspergillus ochraceus</i> culture material. The concentrations of OTA in plasma collected at 0, 5, 10, 15, 20, 30, 45 min, and at 1, 1.5, 2, 3, 6, 9, 12, 24, 48, 72, 96 and 120 h were detected by HPLC. OTA eliminated in urine and feces were quantified at 6-h intervals up to 24 h and then at 4-h intervals up to 120 h. The results suggested that the maximum concentration of OTA in plasma was observed at 12 h after administration, with a mean value of 10.34 μg/mL. The total excretion in both urine and feces was about 10% of the intake until 120 h.https://www.mdpi.com/2072-6651/15/2/88toxicokinetictoxicitymycotoxinsochratoxindonkey |
| spellingShingle | Ruifen Kang Honglei Qu Yanxin Guo Mengjie Zhang Tianze Fu Shimeng Huang Lihong Zhao Jianyun Zhang Cheng Ji Qiugang Ma Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys Toxins toxicokinetic toxicity mycotoxins ochratoxin donkey |
| title | Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys |
| title_full | Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys |
| title_fullStr | Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys |
| title_full_unstemmed | Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys |
| title_short | Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys |
| title_sort | toxicokinetics of a single oral dose of ota on dezhou male donkeys |
| topic | toxicokinetic toxicity mycotoxins ochratoxin donkey |
| url | https://www.mdpi.com/2072-6651/15/2/88 |
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