Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.

Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.

SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy metabolism and mitochondrial function. SIRT3 activates several mitochondrial enzymes, SIRT4 represses its targets, and SIRT5 has been shown to both activate and repress mitochondrial enzymes. To gain insight i...

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Bibliographic Details
Main Authors: Michelle Barbi de Moura, Radha Uppala, Yuxun Zhang, Bennett Van Houten, Eric S Goetzman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4148395?pdf=render

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