Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation
Background: The primary objective of the study was to assess serum 25-hydroxyvitamin D [25(OH)D] values in patients with Cushing’s disease (CD), compared to controls. The secondary objective was to assess the response to a load of 150,000 U of cholecalciferol. Methods: In 50 patients with active CD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/973 |
| _version_ | 1797474207543590912 |
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| author | Valentina Guarnotta Francesca Di Gaudio Carla Giordano |
| author_facet | Valentina Guarnotta Francesca Di Gaudio Carla Giordano |
| author_sort | Valentina Guarnotta |
| collection | DOAJ |
| description | Background: The primary objective of the study was to assess serum 25-hydroxyvitamin D [25(OH)D] values in patients with Cushing’s disease (CD), compared to controls. The secondary objective was to assess the response to a load of 150,000 U of cholecalciferol. Methods: In 50 patients with active CD and 48 controls, we evaluated the anthropometric and biochemical parameters, including insulin sensitivity estimation by the homeostatic model of insulin resistance, Matsuda Index and oral disposition index at baseline and in patients with CD also after 6 weeks of cholecalciferol supplementation. Results: At baseline, patients with CD showed a higher frequency of hypovitaminosis deficiency (<i>p</i> = 0.001) and lower serum 25(OH)D (<i>p</i> < 0.001) than the controls. Six weeks after cholecalciferol treatment, patients with CD had increased serum calcium (<i>p</i> = 0.017), 25(OH)D (<i>p</i> < 0.001), ISI-Matsuda (<i>p</i> = 0.035), oral disposition index (<i>p</i> = 0.045) and decreased serum PTH (<i>p</i> = 0.004) and total cholesterol (<i>p</i> = 0.017) values than at baseline. Multivariate analysis showed that mean urinary free cortisol (mUFC) was independently negatively correlated with serum 25(OH)D in CD. Conclusions: Serum 25(OH)D levels are lower in patients with CD compared to the controls. Vitamin D deficiency is correlated with mUFC and values of mUFC > 240 nmol/24 h are associated with hypovitaminosis D. Cholecalciferol supplementation had a positive impact on insulin sensitivity and lipids. |
| first_indexed | 2024-03-09T20:26:51Z |
| format | Article |
| id | doaj.art-0da3487285004f689768163ecd5a8b6b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:51Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0da3487285004f689768163ecd5a8b6b2023-11-23T23:32:36ZengMDPI AGNutrients2072-66432022-02-0114597310.3390/nu14050973Vitamin D Deficiency in Cushing’s Disease: Before and After Its SupplementationValentina Guarnotta0Francesca Di Gaudio1Carla Giordano2Department of Health Promotion, Maternal-Infantile Care, Excellence Internal and Specialist Medicine “G. D’Alessandro” [PROMISE], Section of Endocrine Disease and Nutrition, University of Palermo, 90127 Palermo, ItalyBiochemistry Head CQRC Division (Quality Control and Biochemical Risk), Department of Health Promotion, Maternal-Infantile Care, Excellence Internal and Specialist Medicine “G. D’Alessandro” [PROMISE], University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Maternal-Infantile Care, Excellence Internal and Specialist Medicine “G. D’Alessandro” [PROMISE], Section of Endocrine Disease and Nutrition, University of Palermo, 90127 Palermo, ItalyBackground: The primary objective of the study was to assess serum 25-hydroxyvitamin D [25(OH)D] values in patients with Cushing’s disease (CD), compared to controls. The secondary objective was to assess the response to a load of 150,000 U of cholecalciferol. Methods: In 50 patients with active CD and 48 controls, we evaluated the anthropometric and biochemical parameters, including insulin sensitivity estimation by the homeostatic model of insulin resistance, Matsuda Index and oral disposition index at baseline and in patients with CD also after 6 weeks of cholecalciferol supplementation. Results: At baseline, patients with CD showed a higher frequency of hypovitaminosis deficiency (<i>p</i> = 0.001) and lower serum 25(OH)D (<i>p</i> < 0.001) than the controls. Six weeks after cholecalciferol treatment, patients with CD had increased serum calcium (<i>p</i> = 0.017), 25(OH)D (<i>p</i> < 0.001), ISI-Matsuda (<i>p</i> = 0.035), oral disposition index (<i>p</i> = 0.045) and decreased serum PTH (<i>p</i> = 0.004) and total cholesterol (<i>p</i> = 0.017) values than at baseline. Multivariate analysis showed that mean urinary free cortisol (mUFC) was independently negatively correlated with serum 25(OH)D in CD. Conclusions: Serum 25(OH)D levels are lower in patients with CD compared to the controls. Vitamin D deficiency is correlated with mUFC and values of mUFC > 240 nmol/24 h are associated with hypovitaminosis D. Cholecalciferol supplementation had a positive impact on insulin sensitivity and lipids.https://www.mdpi.com/2072-6643/14/5/973glucocorticoidhypercortisolism25-hydroxyvitamin Dcholecalciferol |
| spellingShingle | Valentina Guarnotta Francesca Di Gaudio Carla Giordano Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation Nutrients glucocorticoid hypercortisolism 25-hydroxyvitamin D cholecalciferol |
| title | Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation |
| title_full | Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation |
| title_fullStr | Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation |
| title_full_unstemmed | Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation |
| title_short | Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation |
| title_sort | vitamin d deficiency in cushing s disease before and after its supplementation |
| topic | glucocorticoid hypercortisolism 25-hydroxyvitamin D cholecalciferol |
| url | https://www.mdpi.com/2072-6643/14/5/973 |
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