Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc
99mTc is a radionuclide widely used for imaging diagnosis in nuclear medicine. In Brazil it is obtained by elution from 99Mo-99mTc generators supplied by the Nuclear Energy Research Institute (IPEN). The elution is carried out in radiopharmacy laboratories located in hospitals and clinics. Depending...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2005-10-01
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| Series: | Brazilian Archives of Biology and Technology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700032 |
| _version_ | 1818306591593594880 |
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| author | Bernardo Maranhão Dantas Ana Letícia Almeida Dantas Fábio Luiz Navarro Marques Luiz Bertelli Michael G. Stabin |
| author_facet | Bernardo Maranhão Dantas Ana Letícia Almeida Dantas Fábio Luiz Navarro Marques Luiz Bertelli Michael G. Stabin |
| author_sort | Bernardo Maranhão Dantas |
| collection | DOAJ |
| description | 99mTc is a radionuclide widely used for imaging diagnosis in nuclear medicine. In Brazil it is obtained by elution from 99Mo-99mTc generators supplied by the Nuclear Energy Research Institute (IPEN). The elution is carried out in radiopharmacy laboratories located in hospitals and clinics. Depending of the quality of the generator and conditions of use during the elution process, 99Mo can be extracted from the column of the generator, becoming a radionuclidic impurity of the eluate used for the obtention of the radiopharmaceutical to be administered to the patient. 99Mo emits high-energy photons and beta particles and its presence degrades the quality of the image and unnecessarily increases the radiation dose delivered to the patient. An in-vivo measurement technique was developed to verify the occurrence of internal contamination by 99Mo in nuclear medicine patients. Direct measurements were made in a volunteer who underwent myocardial scintigraphy with 99mTc-sestamibi. The results indicated the presence of internal contamination of the patien by 99Mot. The activity was tracked for several days, and an assessment of the radiation dose from the contaminant 99Mo was made.<br>O 99mTc é um radionuclídeo largamente utilizado em diagnósticos por imagem em medicina nuclear. No Brasil, ele é obtido por eluição de um gerador de 99Mo-99mTc fornecido pelo IPEN. A eluição do gerador é feita nas clínicas onde se realizam os exames. Durante a eluição o 99Mo pode ser carreado da coluna, tornando-se uma impureza radionuclídica do eluato a ser utilizado para a obtenção do radiofármaco administrado ao paciente. O 99Mo emite fótons de alta energia e partículas beta, e sua presença, além de provocar degradação na qualidade da imagem do exame, aumenta desnecessariamente a dose de radiação no paciente. Assim, com o objetivo de verificar a possível ocorrência de contaminação interna por 99Mo em pacientes de medicina nuclear, foi desenvolvida uma técnica de medida in vivo e monitorado um paciente voluntário submetido a cintilografia do miocárdio com 99mTc-sestamibi. Os resultados revelaram a presença de 99Mo no corpo do paciente monitorado. |
| first_indexed | 2024-12-13T06:44:55Z |
| format | Article |
| id | doaj.art-0da36f12a66142d2a91c331922f0eccc |
| institution | Directory Open Access Journal |
| issn | 1516-8913 1678-4324 |
| language | English |
| last_indexed | 2024-12-13T06:44:55Z |
| publishDate | 2005-10-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-0da36f12a66142d2a91c331922f0eccc2022-12-21T23:56:19ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242005-10-0148spe221522010.1590/S1516-89132005000700032Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTcBernardo Maranhão DantasAna Letícia Almeida DantasFábio Luiz Navarro MarquesLuiz BertelliMichael G. Stabin99mTc is a radionuclide widely used for imaging diagnosis in nuclear medicine. In Brazil it is obtained by elution from 99Mo-99mTc generators supplied by the Nuclear Energy Research Institute (IPEN). The elution is carried out in radiopharmacy laboratories located in hospitals and clinics. Depending of the quality of the generator and conditions of use during the elution process, 99Mo can be extracted from the column of the generator, becoming a radionuclidic impurity of the eluate used for the obtention of the radiopharmaceutical to be administered to the patient. 99Mo emits high-energy photons and beta particles and its presence degrades the quality of the image and unnecessarily increases the radiation dose delivered to the patient. An in-vivo measurement technique was developed to verify the occurrence of internal contamination by 99Mo in nuclear medicine patients. Direct measurements were made in a volunteer who underwent myocardial scintigraphy with 99mTc-sestamibi. The results indicated the presence of internal contamination of the patien by 99Mot. The activity was tracked for several days, and an assessment of the radiation dose from the contaminant 99Mo was made.<br>O 99mTc é um radionuclídeo largamente utilizado em diagnósticos por imagem em medicina nuclear. No Brasil, ele é obtido por eluição de um gerador de 99Mo-99mTc fornecido pelo IPEN. A eluição do gerador é feita nas clínicas onde se realizam os exames. Durante a eluição o 99Mo pode ser carreado da coluna, tornando-se uma impureza radionuclídica do eluato a ser utilizado para a obtenção do radiofármaco administrado ao paciente. O 99Mo emite fótons de alta energia e partículas beta, e sua presença, além de provocar degradação na qualidade da imagem do exame, aumenta desnecessariamente a dose de radiação no paciente. Assim, com o objetivo de verificar a possível ocorrência de contaminação interna por 99Mo em pacientes de medicina nuclear, foi desenvolvida uma técnica de medida in vivo e monitorado um paciente voluntário submetido a cintilografia do miocárdio com 99mTc-sestamibi. Os resultados revelaram a presença de 99Mo no corpo do paciente monitorado.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700032Molybdenum 99technetium 99mnuclear medicineinternal dosimetryin vivo measurementswhole body counter |
| spellingShingle | Bernardo Maranhão Dantas Ana Letícia Almeida Dantas Fábio Luiz Navarro Marques Luiz Bertelli Michael G. Stabin Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc Brazilian Archives of Biology and Technology Molybdenum 99 technetium 99m nuclear medicine internal dosimetry in vivo measurements whole body counter |
| title | Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc |
| title_full | Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc |
| title_fullStr | Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc |
| title_full_unstemmed | Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc |
| title_short | Determination of 99Mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mTc |
| title_sort | determination of 99mo contamination in a nuclear medicine patient submitted to a diagnostic procedure with 99mtc |
| topic | Molybdenum 99 technetium 99m nuclear medicine internal dosimetry in vivo measurements whole body counter |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700032 |
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