Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan
Background: Transfusion-transmitted cytomegalovirus (TT-CMV) infection can cause severe illness and even death among immunocompromised patients; therefore, the spread of CMV through blood products should be prevented. To our knowledge, no study has been carried out in Pakistan to determine the serop...
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| Format: | Article |
| Language: | English |
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The Running Line
2015-08-01
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| Series: | Advancements in Life Sciences |
| Subjects: | |
| Online Access: | http://www.als-journal.com/245-15/ |
| _version_ | 1827837643010867200 |
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| author | Chahat Batool Rizvi Ali Raza Maria Fareed Siddiqui Rabail Alam |
| author_facet | Chahat Batool Rizvi Ali Raza Maria Fareed Siddiqui Rabail Alam |
| author_sort | Chahat Batool Rizvi |
| collection | DOAJ |
| description | Background: Transfusion-transmitted cytomegalovirus (TT-CMV) infection can cause severe illness and even death among immunocompromised patients; therefore, the spread of CMV through blood products should be prevented. To our knowledge, no study has been carried out in Pakistan to determine the seroprevalence of CMV in general population as well as among blood donors. The goal of this study was to determine CMV seropositivity among blood donors at the blood bank of INMOL Hospital, Lahore, Pakistan.
Methods: A sero-epidemiological cross-sectional study was conducted. Sera from 91 blood donors were screened for CMV specific IgG antibodies by enzyme-linked immunosorbent assay (ELISA) based kit.
Results: The CMV-specific IgG antibodies were detected in 89 blood donors, which gave seroprevalence rate of 97.8%. The statistical analysis of results was done using pearson chi-square test and appeared non-significant with values 0.625 and 0.705 for different age groups and blood groups of donors.
Conclusion: Because of high seroprevalence in this study area, an adequate supply of CMV seronegative blood is difficult to maintain. Therefore, we propose that the future strategies for the prevention of post-transfusion CMV infection in recipients should include the transfusion of leukoreduced blood products. Further a prospective study with much greater population can be done to identify major causative risk factors for such highest prevalence rate. |
| first_indexed | 2024-03-12T06:48:52Z |
| format | Article |
| id | doaj.art-0da3910043724288ad08833b95013ca4 |
| institution | Directory Open Access Journal |
| issn | 2310-5380 2310-5380 |
| language | English |
| last_indexed | 2024-03-12T06:48:52Z |
| publishDate | 2015-08-01 |
| publisher | The Running Line |
| record_format | Article |
| series | Advancements in Life Sciences |
| spelling | doaj.art-0da3910043724288ad08833b95013ca42023-09-03T00:22:14ZengThe Running LineAdvancements in Life Sciences2310-53802310-53802015-08-0124171175Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, PakistanChahat Batool Rizvi0Ali Raza1Maria Fareed Siddiqui2Rabail Alam3Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore-PakistanInstitute of Molecular Biology and Biotechnology, University of Lahore, Lahore-PakistanCenter for Research in Molecular Medicine, University of Lahore, Lahore- PakistanInstitute of Molecular Biology and Biotechnology, University of Lahore, Lahore-PakistanBackground: Transfusion-transmitted cytomegalovirus (TT-CMV) infection can cause severe illness and even death among immunocompromised patients; therefore, the spread of CMV through blood products should be prevented. To our knowledge, no study has been carried out in Pakistan to determine the seroprevalence of CMV in general population as well as among blood donors. The goal of this study was to determine CMV seropositivity among blood donors at the blood bank of INMOL Hospital, Lahore, Pakistan. Methods: A sero-epidemiological cross-sectional study was conducted. Sera from 91 blood donors were screened for CMV specific IgG antibodies by enzyme-linked immunosorbent assay (ELISA) based kit. Results: The CMV-specific IgG antibodies were detected in 89 blood donors, which gave seroprevalence rate of 97.8%. The statistical analysis of results was done using pearson chi-square test and appeared non-significant with values 0.625 and 0.705 for different age groups and blood groups of donors. Conclusion: Because of high seroprevalence in this study area, an adequate supply of CMV seronegative blood is difficult to maintain. Therefore, we propose that the future strategies for the prevention of post-transfusion CMV infection in recipients should include the transfusion of leukoreduced blood products. Further a prospective study with much greater population can be done to identify major causative risk factors for such highest prevalence rate.http://www.als-journal.com/245-15/Human CytomegalovirusBlood donorsSero-prevalenceLeukoreduced bloodPost transfusion CMV infection |
| spellingShingle | Chahat Batool Rizvi Ali Raza Maria Fareed Siddiqui Rabail Alam Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan Advancements in Life Sciences Human Cytomegalovirus Blood donors Sero-prevalence Leukoreduced blood Post transfusion CMV infection |
| title | Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan |
| title_full | Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan |
| title_fullStr | Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan |
| title_full_unstemmed | Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan |
| title_short | Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan |
| title_sort | sero prevalence of human cytomegalovirus among blood donors in lahore pakistan |
| topic | Human Cytomegalovirus Blood donors Sero-prevalence Leukoreduced blood Post transfusion CMV infection |
| url | http://www.als-journal.com/245-15/ |
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