Characteristics and outcomes of pediatric testicular yolk Sac tumor
PurposePediatric testicular yolk sac tumor is a rare malignant germ cell tumor and there is a lack of large clinical studies. The purpose of this study is to summarize the clinical characteristics of pediatric testicular yolk tumor and evaluate the prognostic factors.Materials and methodsThe medical...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1024906/full |
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| author | Maoxian Li Maoxian Li Jinkui Wang Jinkui Wang Jianyu Wang Jianyu Wang Deying Zhang Deying Zhang Yi Hua Yi Hua Feng Liu Feng Liu Peng Lu Peng Lu Junhong Liu Junhong Liu Xing Liu Xing Liu Tao Lin Tao Lin Guanghui Wei Guanghui Wei Dawei He Dawei He Dawei He |
| author_facet | Maoxian Li Maoxian Li Jinkui Wang Jinkui Wang Jianyu Wang Jianyu Wang Deying Zhang Deying Zhang Yi Hua Yi Hua Feng Liu Feng Liu Peng Lu Peng Lu Junhong Liu Junhong Liu Xing Liu Xing Liu Tao Lin Tao Lin Guanghui Wei Guanghui Wei Dawei He Dawei He Dawei He |
| author_sort | Maoxian Li |
| collection | DOAJ |
| description | PurposePediatric testicular yolk sac tumor is a rare malignant germ cell tumor and there is a lack of large clinical studies. The purpose of this study is to summarize the clinical characteristics of pediatric testicular yolk tumor and evaluate the prognostic factors.Materials and methodsThe medical records of children with testicular yolk sac tumor in one pediatric medical centre in China from January 2005 to January 2021 were retrospectively investigated. Data regarding clinical characteristics, treatment and prognosis were collected.ResultsA total of 109 patients with a median diagnosed age of 18 months (range 2–69) were included in this study; of them 100 were diagnosed as stage I, 6 as stage II and 3 as stage IV. All patients underwent radical orchiectomy, and 61 of them underwent postoperative chemotherapy. The mean follow-up time was 61.3 months (range 3–259), during that time, 8 patients experienced relapse. The five-year overall survival was 90.6% (95% CI 84.6%–96.7%). Univariate Cox regression analysis showed that disease stage, relapse, maximum tumor diameter, and alpha-fetoprotein returning to normal within 2 months postoperatively were risk factors for survival (HRs of 25.43, 26.43, 1.48 and 0.08, respectively, p < 0.05). Multivariate Cox regression analysis suggested that higher disease stage and relapse were independent adverse factors for survival (HRs of 148.30 and 94.58, respectively, p < 0.05).ConclusionsThe prognosis of pediatric testicular yolk sac tumor is generally excellent. A higher disease stage and the occurrence of relapse could predict a poor prognosis. The individualized management of children with testicular yolk sac tumor according to risk classification is feasible. |
| first_indexed | 2024-04-11T05:46:20Z |
| format | Article |
| id | doaj.art-0da3a78cab24475ca38eff369feec51f |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T05:46:20Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-0da3a78cab24475ca38eff369feec51f2022-12-22T04:42:12ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-12-011010.3389/fped.2022.10249061024906Characteristics and outcomes of pediatric testicular yolk Sac tumorMaoxian Li0Maoxian Li1Jinkui Wang2Jinkui Wang3Jianyu Wang4Jianyu Wang5Deying Zhang6Deying Zhang7Yi Hua8Yi Hua9Feng Liu10Feng Liu11Peng Lu12Peng Lu13Junhong Liu14Junhong Liu15Xing Liu16Xing Liu17Tao Lin18Tao Lin19Guanghui Wei20Guanghui Wei21Dawei He22Dawei He23Dawei He24Department of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Higher Institution Engineering Research Center of Children's Medical Big Data Intelligent Application, Children's Hospital of Chongqing Medical University, Chongqing, ChinaPurposePediatric testicular yolk sac tumor is a rare malignant germ cell tumor and there is a lack of large clinical studies. The purpose of this study is to summarize the clinical characteristics of pediatric testicular yolk tumor and evaluate the prognostic factors.Materials and methodsThe medical records of children with testicular yolk sac tumor in one pediatric medical centre in China from January 2005 to January 2021 were retrospectively investigated. Data regarding clinical characteristics, treatment and prognosis were collected.ResultsA total of 109 patients with a median diagnosed age of 18 months (range 2–69) were included in this study; of them 100 were diagnosed as stage I, 6 as stage II and 3 as stage IV. All patients underwent radical orchiectomy, and 61 of them underwent postoperative chemotherapy. The mean follow-up time was 61.3 months (range 3–259), during that time, 8 patients experienced relapse. The five-year overall survival was 90.6% (95% CI 84.6%–96.7%). Univariate Cox regression analysis showed that disease stage, relapse, maximum tumor diameter, and alpha-fetoprotein returning to normal within 2 months postoperatively were risk factors for survival (HRs of 25.43, 26.43, 1.48 and 0.08, respectively, p < 0.05). Multivariate Cox regression analysis suggested that higher disease stage and relapse were independent adverse factors for survival (HRs of 148.30 and 94.58, respectively, p < 0.05).ConclusionsThe prognosis of pediatric testicular yolk sac tumor is generally excellent. A higher disease stage and the occurrence of relapse could predict a poor prognosis. The individualized management of children with testicular yolk sac tumor according to risk classification is feasible.https://www.frontiersin.org/articles/10.3389/fped.2022.1024906/fulltesticular yolk sac tumorpediatricrelapsechemotherapyprognosis |
| spellingShingle | Maoxian Li Maoxian Li Jinkui Wang Jinkui Wang Jianyu Wang Jianyu Wang Deying Zhang Deying Zhang Yi Hua Yi Hua Feng Liu Feng Liu Peng Lu Peng Lu Junhong Liu Junhong Liu Xing Liu Xing Liu Tao Lin Tao Lin Guanghui Wei Guanghui Wei Dawei He Dawei He Dawei He Characteristics and outcomes of pediatric testicular yolk Sac tumor Frontiers in Pediatrics testicular yolk sac tumor pediatric relapse chemotherapy prognosis |
| title | Characteristics and outcomes of pediatric testicular yolk Sac tumor |
| title_full | Characteristics and outcomes of pediatric testicular yolk Sac tumor |
| title_fullStr | Characteristics and outcomes of pediatric testicular yolk Sac tumor |
| title_full_unstemmed | Characteristics and outcomes of pediatric testicular yolk Sac tumor |
| title_short | Characteristics and outcomes of pediatric testicular yolk Sac tumor |
| title_sort | characteristics and outcomes of pediatric testicular yolk sac tumor |
| topic | testicular yolk sac tumor pediatric relapse chemotherapy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1024906/full |
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