Kisspeptin/Kisspeptin Receptor System in the Ovary
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00365/full |
| _version_ | 1818606419425886208 |
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| author | Kai-Lun Hu Hongcui Zhao Hsun-Ming Chang Yang Yu Jie Qiao |
| author_facet | Kai-Lun Hu Hongcui Zhao Hsun-Ming Chang Yang Yu Jie Qiao |
| author_sort | Kai-Lun Hu |
| collection | DOAJ |
| description | Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide variety of signals via its binding to KISS1R. Experimental data gathered recently suggest a putative role of kisspeptin signaling in the direct control of ovarian function, including follicular development, oocyte maturation, steroidogenesis, and ovulation. Dysregulation or naturally occurring mutations of the kisspeptin/KISS1R system may negatively affect the ovarian function, leading to reproductive pathology or female infertility. A comprehensive understanding of the expression, actions, and underlying molecular mechanisms of this system in the human ovary is essential for novel approaches to therapeutic and diagnostic interventions in reproductive diseases and infertility. |
| first_indexed | 2024-12-16T14:10:33Z |
| format | Article |
| id | doaj.art-0da3db4bb2b648aaa3faf8b56de165f1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T14:10:33Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0da3db4bb2b648aaa3faf8b56de165f12022-12-21T22:28:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-01-01810.3389/fendo.2017.00365331073Kisspeptin/Kisspeptin Receptor System in the OvaryKai-Lun Hu0Hongcui Zhao1Hsun-Ming Chang2Yang Yu3Jie Qiao4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaKisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide variety of signals via its binding to KISS1R. Experimental data gathered recently suggest a putative role of kisspeptin signaling in the direct control of ovarian function, including follicular development, oocyte maturation, steroidogenesis, and ovulation. Dysregulation or naturally occurring mutations of the kisspeptin/KISS1R system may negatively affect the ovarian function, leading to reproductive pathology or female infertility. A comprehensive understanding of the expression, actions, and underlying molecular mechanisms of this system in the human ovary is essential for novel approaches to therapeutic and diagnostic interventions in reproductive diseases and infertility.http://journal.frontiersin.org/article/10.3389/fendo.2017.00365/fullkisspeptinkisspeptin receptorovarian functionfollicular developmentoocyte maturationovulation |
| spellingShingle | Kai-Lun Hu Hongcui Zhao Hsun-Ming Chang Yang Yu Jie Qiao Kisspeptin/Kisspeptin Receptor System in the Ovary Frontiers in Endocrinology kisspeptin kisspeptin receptor ovarian function follicular development oocyte maturation ovulation |
| title | Kisspeptin/Kisspeptin Receptor System in the Ovary |
| title_full | Kisspeptin/Kisspeptin Receptor System in the Ovary |
| title_fullStr | Kisspeptin/Kisspeptin Receptor System in the Ovary |
| title_full_unstemmed | Kisspeptin/Kisspeptin Receptor System in the Ovary |
| title_short | Kisspeptin/Kisspeptin Receptor System in the Ovary |
| title_sort | kisspeptin kisspeptin receptor system in the ovary |
| topic | kisspeptin kisspeptin receptor ovarian function follicular development oocyte maturation ovulation |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2017.00365/full |
| work_keys_str_mv | AT kailunhu kisspeptinkisspeptinreceptorsystemintheovary AT hongcuizhao kisspeptinkisspeptinreceptorsystemintheovary AT hsunmingchang kisspeptinkisspeptinreceptorsystemintheovary AT yangyu kisspeptinkisspeptinreceptorsystemintheovary AT jieqiao kisspeptinkisspeptinreceptorsystemintheovary |